Results 41 to 50 of about 38,429 (340)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Clinical factors affecting depression in patients with painful temporomandibular disorders during the COVID-19 pandemic

Scientific Reports, 2022
Temporomandibular disorders (TMD) are a multifactorial condition associated with both physical and psychological factors. Stress has been known to trigger or worsens TMD.
Yeon-Hee Lee, Q-Schick Auh
doaj   +1 more source

Parameter estimation in Cox models with missing failure indicators and the OPPERA study [PDF]

, 2015
In a prospective cohort study, examining all participants for incidence of the condition of interest may be prohibitively expensive. For example, the "gold standard" for diagnosing temporomandibular disorder (TMD) is a physical examination by a trained ...
Bair, Bender, Chen, Cook, Dodd, Dworkin, Efron, Fillingim, Gijbels, Greenspan, Little, Magaret, Magder, Maixner, Maixner, McKeague, Ohrbach, Rubin, Rubin, Slade, Slade, Smith, Subramanian   +22 more
core   +3 more sources

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Akt2 inhibition alleviates temporomandibular joint osteoarthritis by preventing subchondral bone loss

Arthritis Research & Therapy
Background This study aimed to investigate the role and mechanism of the Akt2 pathway in different stages of anterior disc displacement (ADD)-induced temporomandibular joint osteoarthritis (TMJOA).
Shi-Yang Feng, Meng-Nan Cao, Chen-Chen Gao, Yi-Xin Li, Jie Lei, Kai-Yuan Fu   +5 more
doaj   +1 more source

Age‐related radiomorphometric changes on panoramic radiographs

Clinical and Experimental Dental Research, 2021
Objectives We aimed to analyse age‐related anatomical changes in teeth and mandibular structures using panoramic radiographs. Materials and Methods We included 471 subjects aged 13–70 years (mean, 35.12 ± 18.72 years).
Yeon‐Hee Lee, Q‐Schick Auh, Yang‐Hyun Chun, Jung‐Sub An   +3 more
doaj   +1 more source

Third molar removal and orofacial pain : a population-based survey [PDF]

, 2010
Peer reviewedPublisher ...
Blinkhorn, Anthony S, Coulthard, Paul, MacFarlane, Tatiana, Stevenson, Laura J   +3 more
core   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Effect of standardized training in combination with masseter sensitization on corticomotor excitability in bruxer and control individuals: a proof of concept study

Scientific Reports, 2022
Recently, it has been proposed that bruxism could represent an overlearned behavior due to the absence of corticomotor plasticity following a relevant tooth-clenching task (TCT).
Noéli Boscato, Fernando G. Exposto, Yuri M. Costa, Peter Svensson   +3 more
doaj   +1 more source

Analgesic potential of different available commercial brands of botulinum neurotoxin-A in formalin-induced orofacial pain in mice

Toxicon: X, 2021
The use of botulinum neurotoxin-A (BoNT-A) is an alternative for the management of orofacial pain disorders. Although only Botox has labeled, there are other commercial brands available for use, among them: Dysport, Botulift, Prosigne, and Xeomin.
Thays Crosara Abrahão Cunha, Ana Claudia Gontijo Couto, Eduardo Januzzi, Rafael Tardin Rosa Ferraz Gonçalves, Graziella Silva, Cassia Regina Silva   +5 more
doaj   +1 more source