Results 211 to 220 of about 124,112 (267)

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

The impact of China's drug regulatory reform on access to orphan drugs: a cross-sectional study of diseases listed in the rare disease catalog. [PDF]

Front Pharmacol
Lan Y, Lin X, Huang Z, Zan W.
europepmc   +1 more source

Dietary melatonin and its benefits on cardiovascular disease

British Journal of Pharmacology, EarlyView.
Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane, Carmelita Abrahams, Sandrine Lecour   +2 more
wiley   +1 more source

Pulmonary vascular reactivity in severe pulmonary hypertension associated with COPD. [PDF]

ERJ Open Res
Jutant EM, Delarche B, Croquette M, Beurnier A, Diaz A, Bironneau V, Caron F, Riou M, Boucly A, Jaïs X, Savale L, Sitbon O, Bertoletti L, Humbert M, Montani D.   +14 more
europepmc   +1 more source

Under the radar: a longitudinal exploration of mental health among children and adolescents experiencing parental and caregiver death during the COVID‐19 pandemic in South Africa

Child and Adolescent Mental Health, EarlyView.
Background Death of a caregiver during childhood can have profound influences on child wellbeing and later trajectories. Globally, child and adolescent mental health is an increasing area of concern with widespread negative implications. These data provide the first comprehensive exploration of the mental health of children experiencing COVID‐19 ...
Kathryn Steventon Roberts, Christina A. Laurenzi, Tatenda Mawoyo, Stefani Du Toit, Mark Tomlinson, Lucie Cluver, Lorraine Sherr   +6 more
wiley   +1 more source

Predictors of treatment outcomes in group cognitive behavioural therapy for orphaned adolescents in sheltered homes. [PDF]

Front Psychiatry
Ding WE, Mukhtar F.
europepmc   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Neuroendocrine Tumors Have Outgrown the Orphan-Disease Framework: Building an Evidence Base for a Changing Field. [PDF]

Cancers (Basel)
Chauhan A, Del Rivero J.
europepmc   +1 more source

Long‐term efficacy and safety of romiplostim plus immunosuppressive therapy as first‐line treatment in patients with aplastic anaemia: 2‐year interim analysis of observational study of two clinical trials

British Journal of Haematology, EarlyView.
Jong Wook Lee, Kohei Hosokawa, Jun Ho Jang, Naoshi Obara, Masashi Sawa, Kensuke Usuki, Gaku Oshikawa, Masahiro Kizaki, Koji Nagafuji, Ting‐An Lin, Hitoshi Hanamoto, Yeung‐Chul Mun, Toshiro Kawakita, Kazunori Imada, June‐Won Cheong, Sung‐Soo Park, Takayuki Tabayashi, Masaru Gamou, Kenta Murotani, Hirohito Yamazaki   +19 more
wiley   +1 more source

The Long Shadow of Institutionalisation: Professional Perspectives on Supporting Care Leavers in Old Age

Child &Family Social Work, EarlyView.
ABSTRACT Forgotten Australians—those who spent time in institutional or out‐of‐home care as children until the 1980s—form a marginalised and often overlooked group within Australia's ageing population. Although formally recognized under the Aged Care Act, their distinct needs remain largely invisible in mainstream aged care.
Lena Turnbull, Sarah Morris, Philip Mendes, Susan Baidawi   +3 more
wiley   +1 more source