Results 21 to 30 of about 86,084 (265)
Orphans in the Market: The History of Orphan Drug Policy [PDF]
Social History of Medicine, 2017 Summary This paper examines the history of orphan drug policy, from the emergence of ‘orphans’ in the American pharmaceutical market in the 1960s, through the debates and agitations that resulted in the passage of the US Orphan Drug Act of 1983, to attempts in the 1990s to prevent abuse of that Act and restore its original intentions ...
openaire +3 more sources
Remote homology and the functions of metagenomic dark matter
Frontiers in Genetics, 2015 Predicted open reading frames (ORFs) that lack detectable homology to known proteins are termed ORFans. Despite their prevalence in metagenomes, the extent to which ORFans encode real proteins, the degree to which they can be annotated, and their ...
Briallen eLobb +3 more
doaj +1 more source
Frontiers in Pharmacology, 2015 Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery.
Nicola J Smith, Nicola J Smith
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Orphanet Journal of Rare Diseases, 2021 Background Orphan drug designations are a useful proxy to investigate trends in rare disease drug development. Drug developers must receive a designation before they are eligible for the economic incentives of the Orphan Drug Act in the United States. We
Kathleen L. Miller +2 more
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Preliminary Cross-Sectional Screening for the Assessment of Macronutrient Consumption and Body Mass Index in Orphans Aged 7 to 15 Years in Amman, Jordan [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعية, 2018 The aim of this study was to screen for malnutrition by evaluating macronutrient intake and calculating the ratio of body mass index (BMI) to age of orphans in 7 selected governmental orphanages in Amman, Jordan.
Hadeel Ghazzawi
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Üsküdar Şer’iyye Sicillerine Göre Eytam Mallarının Finansal Kullanımı (1850-1856)
Kocatepe İslami İlimler Dergisi, 2023 Osmanlı Devleti’ndeki finansal sistem, İslam hukuku çerçevesinde şekillenirken, özellikle klasik dönemde yerel düzeyde kalmış, Tanzimat Fermanı’nın ilanından sonra ise merkezî bir hal kazanarak kurumsallaşma sürecine girmiştir.
Necla Kızıldağ, Mustafa Güler
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Tillfällighetsmodrande och föräldralösa barn i amerikanska post-9/11-romaner
Kvinder, Køn & Forskning, 2015 This article explores how ideas about national identity are staged and critiqued through representations of family relations in two American post-9/11 novels, focusing more specifically on mothering and the orphan child.
Helena Wahlström Henriksson
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Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Community-based Psychosocial Support for Orphan and Vulnerable Children living in an Orphanage
Journal of Innovation and Applied Technology, 2023 Orphan and children living in orphanages are a high-risk group vulnerable to psychosocial problems. Individual who lived in this community are not only orphans but also children and people from low-income families.
Ridhoyanti Hidayah +2 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source