Results 11 to 20 of about 1,419,402 (298)

Contribution of psychoactive substance use and other environmental factors to adolescent pregnancies in Mexico

Public Health and Toxicology, 2023
Introduction Mexico has the highest prevalence of adolescent pregnancies among all the member countries of the Organization for Economic Co-operation and Development (OECD) with a fertility rate of 70.6 births for every 1000 women aged 15–19 years.
Francisco-Javier Prado-Galbarro, Carlos Sanchez-Piedra, Juan-Manuel Martinez-Nuñez   +2 more
doaj   +1 more source

Regulatory Standards in Orphan Medicinal Product Designation in the EU

Frontiers in Medicine, 2021
Twenty years of orphan regulation in Europe have now elapsed, with almost 2,400 orphan designated medicinal products and more than 190 orphan products authorised in the EU.
Stelios Tsigkos, Segundo Mariz, Maria Elzbieta Sheean, Kristina Larsson, Armando Magrelli, Armando Magrelli, Violeta Stoyanova-Beninska, Violeta Stoyanova-Beninska   +7 more
doaj   +1 more source

FDA orphan products clinical trial grants: assessment of outcomes and impact on rare disease product development

Orphanet Journal of Rare Diseases, 2020
Background The Office of Orphan Products Development (OOPD) of the United States (U.S.) Food and Drug Administration (FDA) has awarded over 700 grants to conduct clinical trials of medicals products for rare diseases since 1983, leading to over 70 ...
Kathleen L. Miller, Christine Mueller, Gumei Liu, Katherine I. Miller Needleman, Janet Maynard   +4 more
doaj   +1 more source

Molecular Interactions between Gasotransmitters in Patients with Obstructive Sleep Apnea

International Journal of Translational Medicine, 2022
Patients with obstructive sleep apnea (OSA) have an increased risk of cardiovascular disease (CVD). Nitric oxide (NO) and heme oxygenase-1 (HO-1) affect vascular tone and are vasoprotective.
Snigdha Pusalavidyasagar, Laurie B. Hovde, Jessie Lee, Lei Zhang, Adnan Abbasi, Reena V. Kartha   +5 more
doaj   +1 more source

N-Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy

Biomedicines, 2021
The accumulation of saturated very long-chain fatty acids (VLCFA, ≥C22:0) due to peroxisomal impairment leads to oxidative stress and neurodegeneration in X-linked adrenoleukodystrophy (ALD).
Jie Zhou, Marcia R. Terluk, Paul J. Orchard, James C. Cloyd, Reena V. Kartha   +4 more
doaj   +1 more source

N-acetylcysteine Pharmacology and Applications in Rare Diseases—Repurposing an Old Antioxidant

Antioxidants, 2023
N-acetylcysteine (NAC), a precursor of cysteine and, thereby, glutathione (GSH), acts as an antioxidant through a variety of mechanisms, including oxidant scavenging, GSH replenishment, antioxidant signaling, etc. Owing to the variety of proposed targets,
Siddhee A. Sahasrabudhe, Marcia R. Terluk, Reena V. Kartha   +2 more
doaj   +1 more source

Defining Satisfactory Methods of Treatment in Rare Diseases When Evaluating Significant Benefit–The EU Regulator's Perspective

Frontiers in Medicine, 2021
Since the implementation of the EU Orphan Regulation in 2000, the Committee for Orphan Medicinal Products at the European Medicines Agency has been evaluating the benefits of proposed orphan medicines vs. satisfactory treatment methods.
Maria E. Sheean, Frauke Naumann-Winter, Frauke Naumann-Winter, Giuseppe Capovilla, Giuseppe Capovilla, Giuseppe Capovilla, Maria Elisabeth Kalland, Maria Elisabeth Kalland, Eva Malikova, Eva Malikova, Eva Malikova, Segundo Mariz, Darius Matusevicius, Darius Matusevicius, Robert Nistico, Robert Nistico, Brigitte Schwarzer-Daum, Brigitte Schwarzer-Daum, Stelios Tsigkos, Kyriaki Tzogani, Kristina Larsson, Armando Magrelli, Armando Magrelli, Violeta Stoyanova-Beninska, Violeta Stoyanova-Beninska   +24 more
doaj   +1 more source

Impact of environmental and individual factors on COVID-19 mortality in children and adolescents in Mexico: An observational study

The Lancet Regional Health. Americas, 2022
Summary: Background: During the Covid-19 pandemic, children and adolescents faced poverty, potentially dying from preventable causes, or missing out essential vaccines.
Carlos Sanchez-Piedra, Ana-Estela Gamiño-Arroyo, Copytzy Cruz-Cruz, Francisco-Javier Prado-Galbarro   +3 more
doaj   +1 more source

Copyright and the Regulation of Orphan Works: A Comparative Review of Seven Jurisdictions, and a Rights Clearance Simulation [PDF]

, 2013
About This report is a collaboration between the Centre for Intellectual Property Policy & Management (www.cippm.org.uk), Bournemouth University (BU), the Department for Human Resources & Organisational Behaviour, The Business School, BU, and CREATe ...
Secchi, Davide, Homberg, F., Favale, Marcella, Kretschmer, Martin, Homberg, Fabian, Kretschmer, M., Mendis, Dinusha, Mendis, D., Favale, M.   +8 more
core   +3 more sources

N-acetylcysteine Provides Cytoprotection in Murine Oligodendrocytes through Heme Oxygenase-1 Activity

Biomedicines, 2020
Oligodendrocytic injury by oxidative stress can lead to demyelination, contributing to neurodegeneration. We investigated the mechanisms by which an antioxidant, N-acetylcysteine (NAC), reduces oxidative stress in murine oligodendrocytes.
Jie Zhou, Marcia R. Terluk, Lisa Basso, Usha R. Mishra, Paul J. Orchard, James C. Cloyd, Henning Schröder, Reena V. Kartha   +7 more
doaj   +1 more source