Results 231 to 240 of about 1,419,402 (298)

The rs10781468 Genetic Polymorphism of the Gαq (GNAQ) Gene Is Associated With Responsiveness to Opioid Analgesics in Patients With Postoperative and Cancer Pain: An Exploratory Study

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
In our exploratory hypothesis‐generating study using patients with postoperative pain and cancer pain, for rs10781468 in the GNAQ gene, the minor allele was associated with reduced opioid consumption and an increased pain threshold. ABSTRACT Background G protein–coupled receptors, the largest class of cell surface receptors, are ubiquitously expressed ...
Hiroaki Owada, Daisuke Nishizawa, Tsutomu Mieda, Miki Tsujita, Hideyuki Nakagawa, Shigeki Yamaguchi, Rikuhei Tsuchida, Yaeko Yokoshima, Akira Kitamura, Masakazu Hayashida, Ken‐ichi Fukuda, Tatsuya Ichinohe, Kazutaka Ikeda, Makoto Kurano, Masahiko Sumitani, Kanji Uchida   +15 more
wiley   +1 more source

Engineering compact Physalis peruviana (goldenberry) to promote its potential as a global crop

PLANTS, PEOPLE, PLANET, Volume 8, Issue 5, Page 1550-1556, September 2026.
Goldenberry (Physalis peruviana) produces sweet, nutritionally rich berries, yet like many minor crops, is cultivated in limited geographical regions and has not been a focus of breeding programs for trait enhancement. Leveraging knowledge of plant architecture‐related traits from related species, we used CRISPR/Cas9‐mediated gene editing to generate a
Miguel Santo Domingo, Blaine Fitzgerald, Gina M. Robitaille, Srividya Ramakrishnan, Kerry Swartwood, Nicholas G. Karavolias, Michael C. Schatz, Joyce Van Eck, Zachary B. Lippman   +8 more
wiley   +1 more source

Antimicrobial Resistance Among Selected Zoonotic Bacteria: A Case Study of Tortoises and Birds at the Uganda Wildlife Conservation Education Centre

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study investigated antimicrobial resistance in birds and tortoises at the Uganda Wildlife Conservation Education Centre. Escherichia coli predominated in birds, whereas Salmonella enteritidis predominated in tortoises with resistance to sulphonamides detected.
Delilah Diana Namara, Paul Ssajjakambwe, Sarah Robinah Nakabuye, Vanessa Alyj Katabazi, Celsus Sente   +4 more
wiley   +1 more source

The Mutable Original: How Chinese Counterfeits Become Nigerian Originals in African Markets

American Anthropologist, Volume 128, Issue 3, Page 581-594, September 2026.
ABSTRACT Affordable Chinese copies of Western brands are ubiquitous in African markets. Despite democratizing consumer access, these goods appear to cement hegemonic value hierarchies that rank Chinese or local products as inferior to Western goods.
Jing Jing Liu
wiley   +1 more source

Genotype‐Dependent Effects of Mechanical Stretch and GATA4‐Targeted Compound 3i‐1262 in Cardiomyopathy Patient–Derived hiPSC‐Cardiomyocytes

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Genetic hypertrophic and dilated cardiomyopathies (HCM and DCM, respectively) are characterised by structural and functional abnormalities that can lead to heart failure. However, current therapies mainly reduce symptoms. Patient‐derived human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes provide a valuable platform to study ...
Saana Pohjavaara, Sini M. Kinnunen, Heikki Ruskoaho, Katriina Aalto‐Setälä, Mika J. Välimäki, Virpi Talman   +5 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, Volume 16, Issue 8, Page 1593-1601, August 2026.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Exploratory Analysis of the Inhibitory Effects of Propranolol on NLRP3 and Pyrin Inflammasomes

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective Propranolol, a nonselective beta receptor blocking agents, impacts cAMP levels and is commonly used to treat hypertension and hemangioma in children and adults. Although there are reports indicating its anti‐inflammatory properties, the exact mechanism is not fully understood. Methods Murine and human monocytes and macrophages were exposed to
Renske J. de Jong, Christopher T. Neullens, Aljoscha Swoboda, Melanie Saers, Philipp Berger, Sudheendra Hebbar Subramanyam, Anastasia Wiener, Kim Ohl, Ralf Weiskirchen, Heidi Noels, Tilmann Kallinich, Julia Guthrie, Christoph Kessel, Klaus Tenbrock   +13 more
wiley   +1 more source

Signaling Pathway–Biomarker Coupling for Precision Therapy in Rheumatoid Arthritis: Mechanistic Insights, Translational Bottlenecks, and Emerging Strategies

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease. Despite advances in targeted therapies, significant interindividual variability in treatment response and a lack of precise predictive tools limit the achievement of treat‐to‐target goals.
Shijie Meng, Feng Xing, Yuyang Luo, Jianxin Li, Yingchen Ni, Fengyuan Zhang, Hua Xu, Youhua Wang, Weidong Zhang   +8 more
wiley   +1 more source

Exploring the Burden on Patients Living With and Receiving Treatment for Immune Thrombocytopenia (ITP): Patient and Physician Perceptions From the ITP World Impact Survey (I‐WISh) 2.0

American Journal of Hematology, Volume 101, Issue 8, Page 1954-1968, August 2026.
ABSTRACT Limited data exist on how patients and physicians perceive immune thrombocytopenia (ITP) symptoms and treatment‐related burden. I‐WISh (ITP World Impact Survey) 2.0 surveyed 1018 patients and 431 physicians in 15 countries to characterize the impact of ITP and its treatments on patients.
Nichola Cooper, James Bussel, Waleed Ghanima, Drew Provan, Yoshiaki Tomiyama, Ming Hou, Donald M. Arnold, Cristina Santoro, Francesco Zaja, Barbara Lovrencic, Mervyn Morgan, Michal Winograd, Jennifer DiRaimo, Danielle Boyle, Olivera Rajkovic‐Hooley, Meritxell Vendranas, Susan Frade, Caroline Kruse   +17 more
wiley   +1 more source