Results 251 to 260 of about 3,868,024 (353)

Nervonic acid, a long chain monounsaturated fatty acid, improves mitochondrial function in adrenomyeloneuropathy fibroblasts

British Journal of Pharmacology, Volume 182, Issue 17, Page 4134-4146, September 2025.
Abstract Background and Purpose Nervonic acid plays a vital role in maintaining normal brain and neuronal function. Nervonic acid has gained increasing attention because of its potential neuroprotective and anti‐inflammatory properties. Nonetheless, the beneficial effects of nervonic acid are yet to be fully investigated. Adrenomyeloneuropathy (AMN), a
Chenxu Li, Marcia R. Terluk, Reena V. Kartha   +2 more
wiley   +1 more source

Generic orphan drug substitution: a critical analysis of global practices and Saudi Arabia's perspective. [PDF]

Front Pharmacol
Alakeel YS, Rampakakis E, AlRumaih A, AlRuwaisan R, Abushal M, AlDalaan AM, Idrees MM, Alanazi ZD, AlKoait H, Muaadi A, AlAfra MAM, AlShaya SA, AlHomida S.   +12 more
europepmc   +1 more source

EU FP7 research funding for an orphan drug (Orfadin®) and vaccine (Hep C) development: a success and a failure? [PDF]

J Pharm Policy Pract, 2021
Schmidt L, Sehic O, Wild C.
europepmc   +1 more source

Orphan Drug Approvals In Europe: Historical Review and Trends [PDF]

, 2014
J Rodrigues, D Korchagina, C. Rémuzat, Joan Brunet, F Tavella   +4 more
openalex   +1 more source

Diazoxide--an orphan drug? [PDF]

Archives of Disease in Childhood, 1992
A J Nunn, D C Davidson
openaire   +2 more sources

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

Advancing orphan drug development for rare diseases. [PDF]

Clin Exp Pediatr
Ko JM.
europepmc   +1 more source

Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin

, 2011
Andrew S. Goldsborough, Misty D. Handley, Andrés E. Dulcey, Kristen M. Pluchino, Pavitra Kannan, Kyle R. Brimacombe, Matthew D. Hall, Gary L. Griffiths, Michael M. Gottesman   +8 more
openalex   +2 more sources

Orphan Drug Pricing In France: Influence of Main Factors [PDF]

, 2014
H. Grand, Anne‐Laure Samson, Marine Aulois-Griot   +2 more
openalex   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source