Results 111 to 120 of about 8,062,145 (231)

Siegel, Harry and Sally (Box 91, Folder 16)

, 1987
Series VIII: Audiocassettes features informal oral histories about the Hebrew Orphan Asylum and its alumni.Digital recordingDigital finding ...
Hebrew Orphan Asylum of New York
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Orphan Does Not Always Mean Alone—A Case Study of Eosinophilic Esophagitis, an Orphan Disease

, 2023
Eosinophilic esophagitis (EoE) is a rare immunoinflammatory disease that has recently attracted significant drug development activity. Two EoE drugs have been approved, and clinical trials with several products are ongoing.
Rahnasto, Johanna Raakel
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CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

White, Ed (Box 91, Folder 23)

, 1977
Series VIII: Audiocassettes features informal oral histories about the Hebrew Orphan Asylum and its alumni.Digital recordingDigital finding ...
Hebrew Orphan Asylum of New York
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From research on rare diseases to new orphan drug development [PDF]

, 2010
Rare diseases have a prevalence of lower than 5 in 10,000 inhabitants and are life-threatening or chronically debilitating. It is estimated that worldwide more than 5000 rare diseases exist, which account for over 55 million patients in the EU and the US
Heemstra, H.E., Pharmacoepidemiology, Leufkens, Bert, Büller, H.A., Dep Farmaceutische wetenschappen, Population-based studies of drug treatment: from molecule to patient outcomes, Vrueh, R.L.A., van Weely, S   +7 more
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Ion binding sites and intermediate domain closure induced by D‐serine in the GluD1 ligand‐binding domain

The FEBS Journal, EarlyView.
GluD1 belongs to the ionotropic glutamate receptors and has important functions in the brain and brain diseases. We report the crystal structure of the GluD1 ligand‐binding domain with D‐serine and zinc ions. MD simulations supported promiscuous binding of cations and that chloride ions play a stabilizing role. Pro725 seems to hinder interlobe closure,
Flemming Steen Jørgensen, Emma Grosvald Pedersen, Dilip Narayanan, Karla A. Frydenvang, Jette Sandholm Kastrup   +4 more
wiley   +1 more source

Initial lessons from public-private partnerships in drug and vaccine development

Bulletin of the World Health Organization, 2001
In recent years, venture capital approaches have delivered impressive results in identifying and funding promising health discoveries and bringing them to market.
Wheeler Craig, Berkley Seth
doaj  

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

HOA Interview, Group, Holiday Inn, Lauderdale by the Sea (Box 90, Folder 2)

, 1987
Series VIII: Audiocassettes features informal oral histories about the Hebrew Orphan Asylum and its alumni.Digital recordingDigital finding ...
Hebrew Orphan Asylum of New York
core  

Orphan Drug Reimbursement Trends

, 2023
Background: Orphan drugs are developed to treat rare diseases that affect a small number of individuals. Due to the limited patient demand, orphan drugs are expensive to develop and bring to market.
Teng, Ing
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