Results 191 to 200 of about 22,884 (253)

HTA Evidence in Rare Diseases: Just Rare or Also Special? [PDF]

Pharmacoeconomics
Basu A, Thomas SK, Chapman RH, Spangler J.   +3 more
europepmc   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, Volume 183, Issue 12, Page 3321-3339, June 2026.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

How to alleviate the shortage: a scoping review of prevention and management of global drug shortages. [PDF]

BMC Public Health
Yi Q, Yang N, Zeng L, Huang L, Zou K, Chen J, Luo J, Zhang M, Diao S, Yu Q, Zhu Y, Han L, Zhang L.   +12 more
europepmc   +1 more source

From Precision to Personalized: Catalyzing AI‐Enabled Innovation in Drug Development

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT In 2015, President Obama announced the Precision Medicine Initiative in his nationally televised State of the Union address. The vision was bold: to enable a new era of medicine through research, technology, and policies that empower patients, researchers, and providers to work together toward the development of individualized care.
Adarsh Subbaswamy, Allison Dunn, Brooke Langevin, Sooyoung Lee, Mathangi Gopalakrishnan, Jogarao V. S. Gobburu   +5 more
wiley   +1 more source

Orphan drug propranolol for infantile hemangioma: ten-year real-world safety data from the FAERS database. [PDF]

Orphanet J Rare Dis
Li X, Zhao X, Yang C, Chen A.
europepmc   +1 more source

Strategic Drivers Behind Early Withdrawal of Orphan Designations in the EU: A Retrospective Analysis (2000-2024). [PDF]

Ther Innov Regul Sci
Bouwman L, Castanheira M, Siotis G.
europepmc   +1 more source

Cannabinoid Therapies in Less-Common Disorders: Clinical Evidence and Formulation Strategies. [PDF]

Diseases
Afonso S, Gonçalves J, Brinca AT, Rosendo LM, Rosado T, Duarte AP, Gallardo E.   +6 more
europepmc   +1 more source

The Simultaneous Prevention of Multiple Diseases: A "One Ring to Rule Them All" Framework for Redox-Driven Health and Longevity. [PDF]

Nutrients
Silverstein HR, Rizvanov AA, Haines DD, Mahmoud FF, Rose SC, Solovyeva VV, Kitaeva KV, Tosaki A.   +7 more
europepmc   +1 more source

Nuclear receptors as therapeutic targets in metabolic and cardiovascular disorders. [PDF]

iScience
Li F, Chen Q, Dai Y, Lu L.
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source