Pathing the way from regulatory approval to market access for gene therapy products (GTPs): An integrative review in the US, EU5, Japan and China. [PDF]
Shi J, Hu H, Ung COL.
europepmc +1 more source
How to Imagine Educational AI: The Filling of a Pail or the Lighting of a Fire?
Abstract Recent advances in artificial intelligence (e.g., machine learning, generative AI) have led to increased interest in its application in educational settings. AI companies hope to revolutionize teaching and learning by tailoring material to the individual needs of students, automating parts of teachers' jobs, or analyzing educational data to ...
Michał Wieczorek, Alberto Romele
wiley +1 more source
Can the Development of Orphan Drugs Include Wider Patient Engagement? A Citizens' Jury to Explore a Promissory Notion. [PDF]
Frost J +5 more
europepmc +1 more source
ABSTRACT This article examines the historical displacement of Indigenous peoples in Venezuela, focusing on the links between indigenist policies and the exploitation of natural resources, particularly oil, throughout the 20th century. Using a combined historical and ethnographic approach, it demonstrates how the formation of the Venezuelan nation‐state
Gabriel Tardelli
wiley +1 more source
Consequences of Canada's Drug Agency Reimbursement Recommendations for New Medicines and Pan-Canadian Pharmaceutical Alliance Price Negotiations on Patient Access. [PDF]
Rawson NSB.
europepmc +1 more source
Estimating Correlations Between Clinical Trial Outcomes Using Generalised Estimating Equations
ABSTRACT Accurately estimating the correlations among clinical trial outcomes is crucial for managing the risk of biopharmaceutical investment portfolios. We propose a novel algorithm for estimating correlations in large clinical trial datasets using a generalised estimating equations (GEE) framework.
Yuehao Dai +4 more
wiley +1 more source
Early and accelerated access programs for medical devices in the European Union: mapping regulatory derogations and national schemes. [PDF]
Haon B +4 more
europepmc +1 more source
Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch +13 more
wiley +1 more source
Assessing rare disease understanding: a novel disease readiness level framework. [PDF]
Kitahara K, Kano S.
europepmc +1 more source
Artificial Intelligence Powers Protein Functional Annotation
This review systematically summarizes how artificial intelligence advances protein functional annotation. It organizes existing methods into six unified modeling paradigms and analyzes their applications in Gene Ontology and Enzyme Commission prediction.
Wenkang Wang +4 more
wiley +1 more source

