Results 151 to 160 of about 22,997 (249)

Sustained Effectiveness of Lanadelumab in Preventing Hereditary Angioedema Attacks: The ENABLE Study

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT Background Lanadelumab has been approved for hereditary angioedema (HAE) long‐term prophylaxis since 2018. The Phase 4, prospective ENABLE Study (NCT04130191) evaluated the long‐term effectiveness and safety of lanadelumab in clinical practice across Europe and the Middle East.
Andrea Zanichelli, Walter A. Wuillemin, Markus Magerl, Andreas Recke, Mauro Cancian, Emel Aygören‐Pürsün, Ramón Lleonart Bellfill, Aharon Kessel, Tamar Kinaciyan, Robin Lochbaum, Mona Al‐Ahmad, Irmgard Andresen, Maureen Watt, Natalie Khutoryansky, Daniel N. Castaner, Inmaculada Martinez‐Saguer   +15 more
wiley   +1 more source

GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening. [PDF]

J Am Chem Soc
Schihada H, Shahraki A, Turku-Metsänen A, Rath M, Wirth L, Nemec K, Tselepli H, Heitzer L, Vallaster B, Fadel M, Schulte G, Hilger D, Pockes S, Lohse MJ, Kolb P.   +14 more
europepmc   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 357-374, August 2026.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Can the Development of Orphan Drugs Include Wider Patient Engagement? A Citizens' Jury to Explore a Promissory Notion. [PDF]

Health Expect
Frost J, Widening Engagement Patient Advisory Group, Mandizha J, van den Dungen C, Asare L, Pope C.   +5 more
europepmc   +1 more source

A Tale of Two Mechanisms: The p53 Modulator COTI‐2 Is a Zn Metallochaperone

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Mutations in, or misregulation of, Tp53 are found in approximately 50% of all cancers. p53 functions by ensuring that cells with irretrievably damaged DNA undergo apoptosis. Tp53 mutations often induce conformational changes that inhibit activity; however, small‐molecule chaperones could theoretically restore conformation and activity. COTI‐2,
İrem Şimşek, Farsheed Shahbazi‐Raz, Michael J. Krause, Azam Mohammadzadeh, Maryam Kosar, Peihan Xu, Samra Khan, Olena Tykhoniuk, Ashley DaDalt, Deya'a Almasri, Lara K. Watanabe, Kaitlyn Breault, John J. Hayward, Fraser S. Pick, Richard L. Ho, Jeremy M. Rawson, John F. Trant   +16 more
wiley   +1 more source

Consequences of Canada's Drug Agency Reimbursement Recommendations for New Medicines and Pan-Canadian Pharmaceutical Alliance Price Negotiations on Patient Access. [PDF]

Clinicoecon Outcomes Res
Rawson NSB.
europepmc   +1 more source

2′‐FL's Depiction of the Human Physiological Function Landscape

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The figure summarizes the multifaceted physiological effects of 2′‐fucosyllactose (2′‐FL), a major human milk oligosaccharide. The schematic illustrates the central role of the gut‐centered regulatory axis, where 2′‐FL modulates gut microbiota composition, promotes the production of short‐chain fatty acids and microbial metabolites, enhances mucus ...
Yushan Xiao, Jiahao Li, Xiaofeng Li, Yan Dai   +3 more
wiley   +1 more source

Early and accelerated access programs for medical devices in the European Union: mapping regulatory derogations and national schemes. [PDF]

Front Med Technol
Haon B, Hartmann M, Akodad S, Stevens H, Rochaix L.   +4 more
europepmc   +1 more source

The Role of Immunoresolvents in Atherosclerosis: A Mini‐Review on Their Biology and Therapeutic Opportunities

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Atherosclerosis is a lipid‐induced chronic inflammatory cardiovascular disorder denoted by the infiltration of immune cells and the agglomeration of lipids in the intima, the innermost layer, of the arteries of large and medium sizes.
Ramin Lotfi, Alireza Nasirifar, Hoda Rahmani, Sara Falahi, Meysam Kashiri   +4 more
wiley   +1 more source

Pathing the way from regulatory approval to market access for gene therapy products (GTPs): An integrative review in the US, EU5, Japan and China. [PDF]

Regen Ther
Shi J, Hu H, Ung COL.
europepmc   +1 more source