Results 161 to 170 of about 68,610 (290)

Safety population size and duration of exposure prior to approval of new medicines: A database analysis of medicines centralised approved in the European Union between 2011 and 2023. [PDF]

PLoS One
Bouwman L, Leufkens H, Sepodes B, Torre C.   +3 more
europepmc   +1 more source

Valuing Intellectual Property Rights in an Imperfectly Competitive Market: A Biopharming Application [PDF]

Small research firms developing biotechnology applications often focus on establishing intellectual property rights (IPRs), which can then be sold to more established firms with existing market channels.
Kostandini, Genti, Mills, Bradford F.
core   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Advances in orphan drug development for alpha-1 antitrypsin deficiency: a 2025 update from the FDA and EMA. [PDF]

Ther Adv Respir Dis
Höger P, Ries M, Olivares Rivera A, Ersöz H, Buschulte K, Fähndrich S, Kontogianni K, Herth F, Trudzinski FC.   +8 more
europepmc   +1 more source

Colliding Wars: A Systematic Review on HIV Responses in Conflict‐Affected Settings

Public Health Challenges, Volume 5, Issue 2, June 2026.
Armed conflicts heighten HIV vulnerability among adolescent girls, refugees and displaced populations through service disruptions and health system collapse. This systematic review of 17 studies identifies promising adaptive strategies like mobile clinics and emergency stock packs to sustain HIV care.
Mona Ibrahim, Alhadi Khogali, Eslam Sadeldin, Ethar Abosam, Yejide Okungbaye, Esther Osime, Mohammed F. Adam, Mohamed Elsheikh, Bothaina Eltigani, Janina Jochim, Maysoon Dahab, Rachel Yates, Lucie Cluver   +12 more
wiley   +1 more source

Advancing hypoparathyroidism treatment: FDA approval of Palopegteriparatide as a promising orphan drug. [PDF]

Ann Med Surg (Lond)
Shahid SR, Shahid K, Ehsan S, Khalid M, Waafira A.   +4 more
europepmc   +1 more source

Opportunities and challenges in protein structure prediction

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Deep learning methods, particularly exemplified by AlphaFold2, have revolutionized the field of protein structure prediction—an achievement recognized by the 2024 Nobel Prize in Chemistry awarded to its core developers. Despite this remarkable achievement, the broader protein folding problem is far from solved. Key challenges—each representing
Wenkai Wang, Baoquan Su, Chenxiao Xiang, Jianyi Yang   +3 more
wiley   +1 more source

Informing Dose for Pediatric Rare Diseases-A Survey of Recent Orphan Drugs Approvals. [PDF]

Clin Transl Sci
Fletcher EP, Kim C, Mei H, AbuAsal B, Samuels S, Madabushi R, Ramamoorthy A.   +6 more
europepmc   +1 more source

Federal 340B Program Payment Scheme for Drugs Designated As Orphan Products: Congressional Clarification Needed to Close the Government-Industry Revolving Door [PDF]

Journal of Clinical Oncology, 2016
Yang, Y. Tony, Chen, Brian, Bennett, Charles L.   +2 more
openaire   +2 more sources

When Public Health Becomes the Weapon: Current and Prospective Consequences of the Genocide in Gaza

World Medical &Health Policy, Volume 18, Issue 2, June 2026.
ABSTRACT Catastrophic humanitarian conditions during the 2023–2025 genocide in Gaza have caused a public health crisis of exceptional magnitude. This article summarizes key short‐ and long‐term health consequences for Gaza's civilian population and outlines priorities for recovery.
Therese Alexandra Evald, Nanna Gram Ahlmark, Clara Barfod Parellada, Andreea Micula, Caroline Klint Johannesen, Dana Bdier, Fayez Mahamid, Hilde Lausund, Jane Brandt Sørensen, Maha Aon, Majd Qannita, Maren Johanne Heilskov Rytter, Nanna Maaløe, Nina Jøranson, Sara Aakre Faradonbeh, Vibeke Brix Christensen, Waseem Alzaanin, Sigurd Lauridsen, Helle Timm, Frederik Schou‐Juul   +19 more
wiley   +1 more source