Results 21 to 30 of about 8,062,145 (231)

Lamellar Keratoplasty as a Method of Treatment Patients with Neurotrophic Keratopathy II and III Stages Outcome

Oftalʹmologiâ, 2022
Neurotrophic keratopathy (NTK) is an orphan, polyetiological disease that has recently been identified more frequently. Drug-resistant stages of NTC often require urgent surgical treatment.
M. Ezugbaya, I. A. Riks, S. V. Trufanov, S. Yu. Astakhov, S. S. Papanyan, L. K. Anikina, R. Boutaba, V. V. Gryaznova   +7 more
doaj   +1 more source

Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation. [PDF]

PLoS ONE, 2015
CD4+ T-helper cells that produce interleukin-17 (Th17 cells) are characterized as pathological T-helper cells in autoimmune diseases. Differentiation of human and mouse Th17 cells requires a key transcription regulator, retinoic acid receptor-related ...
Qingfeng Ding, Mei Zhao, Bolan Yu, Chuan Bai, Zhaofeng Huang   +4 more
doaj   +1 more source

Mean values of financial variables for orphan and non-orphan drug companies.

, 2016
Mean values of financial variables for orphan and non-orphan drug companies.
Jannine Poletti-Hughes (3235161), Dyfrig A. Hughes (3235158)   +1 more
core   +1 more source

Overexpression of Neuron-Derived Orphan Receptor 1 (NOR-1) Rescues Cardiomyocytes from Cell Death and Improves Viability after Doxorubicin Induced Stress

Biomedicines, 2021
Following myocardial infarction, reperfusion injury (RI) is commonly observed due to the excessive formation of, e.g., reactive oxygen species (ROS).
Per-Christian Berg, Åse Mari Larsen Hansson, Øystein Røsand, Gurdeep Marwarha, Morten Andre Høydal   +4 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Can a regulatory instrument promote research and development into neglected diseases? A Policy Delphi Survey [PDF]

, 2012
Fehr A. Can a regulatory instrument promote research and development into neglected diseases? A Policy Delphi Survey. Bielefeld: University of Bielefeld; 2012.Background Rare diseases and neglected diseases are characterized by deficits in drug research ...
Fehr, Angela
core  

Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S

Microbial Cell Factories, 2022
Background The anthraquinone-fused 10-membered enediynes (AFEs), represented by tiancimycins (TNMs), possess a unique structural feature and promising potentials as payloads of antitumor antibody–drug conjugates.
Manxiang Zhu, Fan Zhang, Ting Gan, Jing Lin, Yanwen Duan, Xiangcheng Zhu   +5 more
doaj   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Orphan Drug Development: Incentives Under the Orphan Drug Act [PDF]

, 2015
After describing the intellectual property and regulatory environment for orphan drugs in the United States, this thesis compares the investment decisions in the orphan drug market with the larger pharmaceutical industry.
Smith, Sara H D
core  

Pharmaceutical lobbying in Brazil: a missing topic in the public health research agenda

Revista de Saúde Pública
In the US, where registration of lobbyists is mandatory, the pharmaceutical industry and private health-care providers spend huge amounts of money seeking to influence health policies and government decisions. In Brazil, where lobbying lacks transparency,
Francisco José Roma Paumgartten
doaj   +1 more source