Results 71 to 80 of about 160,551 (221)

Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.

Endocrinology, 2015
Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in advanced stages. Mitotane is approved as an orphan drug for treatment of ACC and counteracts tumor growth and steroid hormone production.
S. Sbiera, E. Leich, G. Liebisch, Iuliu Sbiera, A. Schirbel, Laura Wiemer, S. Matysik, C. Eckhardt, Felix Gardill, A. Gehl, Sabine Kendl, I. Weigand, M. Bala, C. Ronchi, T. Deutschbein, G. Schmitz, A. Rosenwald, B. Allolio, M. Fassnacht, M. Kroiss   +19 more
semanticscholar   +1 more source

Genetic variants linked to type 2 diabetes in CDKN1B and TCF7L2 influence survival outcomes in metastatic colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Multiple genetic polymorphisms characteristic of type 2 diabetes (T2D) have been associated with unfavorable prognostic outcomes in individuals with both T2D and metastatic colorectal cancer. This study evaluated the impact of T2D genetic polymorphisms on metastatic colon cancer prognosis in a cohort of non‐diabetic patients.
Raffaella Ruggiero, Alessandro Ottaiano, Madhura Tathode, Roberto Sirica, Annabella Di Mauro, Monica Ianniello, Nadia Petrillo, Massimiliano Berretta, Silvia Zappavigna, Amalia Luce, Michele Caraglia, Giovanni Savarese   +11 more
wiley   +1 more source

Perspectives on stimulating industrial research and development for neglected infectious diseases

Bulletin of the World Health Organization, 2001
This paper summarizes recent thinking on stimulating industrial research and development (R & D) for neglected infectious diseases and argues that it is critical to enlarge the value of the market for medicines and vaccines through, for example, global ...
Webber David, Kremer Michael
doaj  

The Role of Interleukin‐23 and Interleukin‐17 in Peri‐Implant Crevicular Fluid of Subjects With Peri‐Implant Disease: A Systematic Review

Journal of Clinical Laboratory Analysis, EarlyView.
The role of IL‐23/IL‐17 cytokine axis in peri‐implant disease. ABSTRACT Background Activation of the IL‐23/IL‐17 cytokine axis could trigger peri‐implant bone loss. The aim of this review was to analyze whether in people with peri‐implantitis (PI) and peri‐implant mucositis (PM) the concentrations of the interleukin‐23 and interleukin‐17 in peri ...
Mario Alberto Alarcón‐Sánchez, Julieta Sarai Becerra‐Ruiz, Ruth Rodríguez‐Montaño, Sarah Monserrat Lomelí‐Martínez, Lilibeth‐Stephania Escoto‐Vasquez, Artak Heboyan   +5 more
wiley   +1 more source

Analysis on the Influence of Policy Factors in Innovating Behavior for Chinese Orphan Drugs' Industry

, 2014
Because of the small target market and poor profitability of Orphan Drug, it is difficult to effectively encourage the R&D and production Behavior of the Industry by the market mechanisms alone.
Baxian Yi, Guangping Wang, Yanfei Huo, Xiao-Ming Wu   +3 more
semanticscholar   +1 more source

Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.

Natural product reports (Print), 2016
Covering: up to 2015. Over the centuries, microbial secondary metabolites have played a central role in the treatment of human diseases and have revolutionised the pharmaceutical industry.
J. S. Zarins-Tutt, Tania Triscari Barberi, Hong Gao, A. Mearns-Spragg, Lixin Zhang, D. Newman, R. Goss   +6 more
semanticscholar   +1 more source

Streamlining electronic medical record data extraction and validation in digital hospitals: A systematic review to identify optimal approaches and methods

Learning Health Systems, EarlyView.
Abstract Objective Extracting and curating data from large clinical information systems is challenging, and the optimal methodology is often unclear. This review was to systematically investigate and appraise the research literature to assess existing methods used by healthcare organizations to extract data from the electronic medical record (EMR). The
Han Chang Lim, Howard Wong, Reji Philip, Anton Van Der Vegt, Kim‐Kwang Raymond Choo, Jason D. Pole, Clair Sullivan   +6 more
wiley   +1 more source

Recent Advancements in the Treatment of Age‐Related Macular Degeneration

Med Research, EarlyView.
ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu, Danyang Lv, Junran Sun, Huixun Jia, Fang Zheng, Felipe Pereira, Siddharth Narendran, Zhenyu Dong, Haiyun Liu, Shunxiang Gao, Peirong Huang   +10 more
wiley   +1 more source

Orphan products: an emerging trend in drug approvals [PDF]

Nature Reviews Drug Discovery, 2010
M. Miles Braun, M. Ian Phillips, Timothy R. Coté, Kui Xu, Aditya Kelkar   +4 more
openaire   +2 more sources

Battlefield medicine: disrupting (bio) pharmaceutical production

, 2015
Conventional pharmaceutical manufacturing, whose outdated processes are fraught with significant operational and logistical issues, fails to address the ‘on demand’ needs of today’s military and civilian patient populations.
Eugene J. Choi, J. Lewin, Geoffrey S. F. Ling   +2 more
semanticscholar   +1 more source