Results 71 to 80 of about 43,399 (123)
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source
Artificial intelligence streamlines scientific discovery of drug–target interactions
British Journal of Pharmacology, EarlyView.Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose The chemokine receptor CCR6 guides pathogenic T17 cells, implicated in autoimmune diseases including psoriasis, to sites of inflammation via the chemokine CCL20. Therefor, pharmacological inhibition of CCR6+ immune cell migration provides a novel therapeutic approach.
Paulina Kulig +10 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano +6 more
wiley +1 more source
Adolescents: Orphaned and Vulnerable in the Time of HIV/AIDS [PDF]
, 2005 This paper calls for greater attention to orphaned and vulnerable adolescents by agencies working in this ...
Ana-Maria Schweitzer +6 more
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Nervonic acid plays a vital role in maintaining normal brain and neuronal function. Nervonic acid has gained increasing attention because of its potential neuroprotective and anti‐inflammatory properties. Nonetheless, the beneficial effects of nervonic acid are yet to be fully investigated. Adrenomyeloneuropathy (AMN), a
Chenxu Li +2 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou +4 more
wiley +1 more source
Intellectual Property & External Consumption Effects: Generalizations from Pharmaceutical Markets [PDF]
There is a long-standing literature that recognizes that an efficient solution in correcting a consumption externality is through applying subsidies and taxes that line up private incentives with social ones.
Stephane Mechoulan, Tomas Philipson
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Clinical &Experimental Allergy, EarlyView.Through the ‘4As’: Awareness, Access, Advocacy, and Alliance, the Greater Bay Area will continue to leverage its unique advantages to confront ongoing challenges such as diagnostic delays and lack of access to diagnosis and hereditary angioedema (HAE)‐specific medications.
Philip H. Li +22 more
wiley +1 more source