Results 91 to 100 of about 2,987 (243)

Design of experiments‐guided membrane capture facilitates integration of continuous virus inactivation using Phi6 as a surrogate virus in an intensified downstream process

Biotechnology Progress, EarlyView.
Abstract The growing demand for cost‐efficient and flexible biomanufacturing has increased interest in process‐intensified downstream platforms. This study evaluates an intensified monoclonal antibody (mAb) purification sequence, where two unit operations traditionally performed in batch mode—Protein A capture and low pH virus inactivation (VI)—are ...
Mario Grünberg, Lisa Lipski, Gabriel Fisicaro, Thomas Duvignau, Karolina Meyer‐Heinrichs, Diana Carmen Mocsy, Thomas‐Josef Filz, Bastian Quaas, Alexandra Stützer   +8 more
wiley   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Efektifitas Konseling Kelompok Pendekatan SFBC untuk Meningkatkan Resiliensi Yatim Piatu di Panti Asuhan Gatot Soebroto Kota Semarang

Guidena
Changes in conditions in an individual's life give rise to various kinds of reactions that have an impact on behavior. Every individual is required to be strong in facing changes, bad support and emotions make the individual unconscious of the strength ...
Anggun Karomah
doaj   +1 more source

A Comparison of Regional Decisions for Doses and Administrations of New Drugs: Concordance, Discordance, and Dependencies

Clinical Pharmacology &Therapeutics, EarlyView.
Regional differences in approved drug dosages and administration are shaped by complex factors, including clinical data, prior regulatory decisions, and region‐specific considerations. This study investigated how such factors are associated with variations in approved doses across the United States Food and Drug Administration (FDA), European Medicines
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

The Efficacy of "Care for Child Development" Intervention on the Improvement of the Development Skills of Orphanage Children. [PDF]

Iran J Child Neurol, 2023
Baraheni N, Heidarabadi S, Maleki Z, Azhdarzadeh F, Bahari Gharehgoz A, Bagheri Z.   +5 more
europepmc   +1 more source

Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub, Martyn Howard, Brahim Achour, Jill Barber, Naved Alizai, Amin Rostami‐Hodjegan   +5 more
wiley   +1 more source

Sensemaking and CSR Character in Multinational Corporations: A Comparative Study of Headquarters and Subsidiary Practices in the UAE

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT While corporate social responsibility (CSR) scholarship assumes that organizational consistency signals effectiveness, there remains a knowledge gap about how MNCs navigate competing institutional logics between headquarters and subsidiaries. This study investigates how managerial sensemaking mediates the effects of institutional pressures on ...
Charles Antony Diab, Wendy Stubbs
wiley   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Principles of privacy and safety in the design of Syrian orphanages

Архитектон
The analysis of existing orphanages in the city of Aleppo revealed the predominant use of an institutional model in the formation of the architectural volume, which contributes to the isolation of the child from the social community of the city, does not
Akeel Aya, Anisimova Liudmila V.
doaj   +1 more source

Understanding Engagement in Collaborative Governance Networks Through Motivation, Learning, and Values

Environmental Policy and Governance, EarlyView.
ABSTRACT Collaborative governance networks are increasingly central to local climate action, yet research offers limited understanding of the personal, psychological, and informal factors that sustain engagement within them. This paper examines how such networks facilitate meaningful and lasting participation through an in‐depth study of Malmö Works, a
Gustav Osberg
wiley   +1 more source