Results 91 to 100 of about 6,140 (302)
Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, EarlyView.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2019 We consider the regional features of the social protection system of “morally handicapped” children in Tambov province in the first decade of Soviet government (1918–1928).
P. P. Shcherbinin, I. A. Shikunova
doaj +1 more source
HIV infection in orphanages in South Western Nigeria
, 2011 Background: As a result of the expanding HIV epidemic, affected children may end up in institutionalized care. Objectives: To determine the prevalence of HIV infection among children into orphanages in South Western Nigeria .
Brown, BJ +3 more
core +1 more source
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
The orphanage industry: flourishing when it should be dying
Scottish Journal of Residential Child Care, 2018 Deinstitutionalisation of alternative care systems is a major challenge in many countries of Africa and Asia in particular, where care provision is essentially left in the hands of non-State actors and overwhelmingly takes the form of large residential ...
Nigel Cantwell +1 more
doaj +1 more source
, 2005 Medu autorima koji su pisali o nahodištima u Dalmaciji, neobicno je velik doprinos zadarskog lijecnika i povjesnicara Romana Jelica. Njegov je rad znatno obogatio ovo podrucje.
Slavko Perović, Perović, Slavko
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Cancer Nexus, EarlyView.ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang +4 more
wiley +1 more source
THE SOCIOCULTURAL STANDARDS OF UPBRINGING CHILDREN IN THE SIBERIAN ORPHANAGES
, 2016 The article shows the formation and development of socio-cultural standards of upbringing children in orphanages in Siberia (on the example of Novosibirsk).
Lavrenteva, Zoya
core +1 more source
A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders
Clinical Pharmacology &Therapeutics, EarlyView.Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel +3 more
wiley +1 more source
Behavior Problems in Children Adopted from Socially-Emotionally Depriving Orphanages [PDF]
, 2009 Exposure to poor social-emotional conditions during early childhood may contribute to higher rates of behavior problems found among children adopted from orphanages.
Merz, Emily Claire
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