Results 51 to 60 of about 2,987 (243)
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, EarlyView.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Advanced Science, EarlyView.Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao +13 more
wiley +1 more source
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Fatal Respiratory Infections Associated with Rhinovirus Outbreak, Vietnam
Emerging Infectious Diseases, 2012 During an outbreak of severe acute respiratory infections in 2 orphanages, Vietnam, 7/12 hospitalized children died. All hospitalized children and 26/43 children from outbreak orphanages tested positive for rhinovirus versus 9/40 control children (p = 0 ...
Le Thanh Hai +9 more
doaj +1 more source
Preliminary Cross-Sectional Screening for the Assessment of Macronutrient Consumption and Body Mass Index in Orphans Aged 7 to 15 Years in Amman, Jordan [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعية, 2018 The aim of this study was to screen for malnutrition by evaluating macronutrient intake and calculating the ratio of body mass index (BMI) to age of orphans in 7 selected governmental orphanages in Amman, Jordan.
Hadeel Ghazzawi
doaj +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Journal of Indian Association of Public Health Dentistry, 2016 Introduction: Dental caries is a common disease of the childhood affecting the quality of life (QoL). Studies have focused on oral health including caries experience in underprivileged children. However, information concerning relationship between caries
Rohan Pratap +2 more
doaj +1 more source
Advanced Science, EarlyView.Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling +17 more
wiley +1 more source
Науковий вісник Чернівецького національного університету імені Юрія Федьковича. Історія, 2022 This research constitutes a relatively new area which has emerged from the previous study on the Soviet system of institutional care and upbringing of children, in particular, an established system of orphanages in the western regions of Ukraine after ...
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