Results 51 to 60 of about 9,735 (200)

Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20 [PDF]

, 2018
Bunyaviruses pose a significant threat to human health, prosperity and food security. In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon stimulated genes (ISGs) whose cumulative action can potently ...
Bieniasz, Paul D., Brennan, Benjamin, Elliott, Richard M., Feng, Junjie, Koudriakova, Elina, Kreher, Felix, Rezelj, Veronica V., Rice, Charles M., Rihn, Suzannah J., Shaw, Andrew E., Shi, Xiaohong, Slack, Gillian S., Tilston-Lunel, Natasha L., Turnbull, Matthew L., Wickenhagen, Arthur, Wilson, Sam J.   +15 more
core   +1 more source

Mutational Analysis of the Bunyamwera Orthobunyavirus Nucleocapsid Protein Gene [PDF]

Journal of Virology, 2009
ABSTRACT The bunyavirus nucleocapsid protein, N, is a multifunctional protein that encapsidates each of the three negative-sense genome segments to form ribonucleoprotein complexes that are the functional templates for viral transcription and replication. In addition, N protein molecules interact with themselves to form oligomers,
Saleh A, Eifan, Richard M, Elliott
openaire   +2 more sources

Novel murine models for studying Cache Valley virus pathogenesis and in utero transmission

Emerging Microbes and Infections, 2021
Cache Valley virus (CVV) is a prevalent emerging pathogen of significant importance to agricultural and human health in North America. Emergence in livestock can result in substantial agroeconomic losses resulting from the severe embryonic lethality ...
Krisangel López, Sarah N. Wilson, Sheryl Coutermash-Ott, Manette Tanelus, William B. Stone, Danielle L. Porier, Dawn I. Auguste, John A. Muller, Orchid M. Allicock, Sally L. Paulson, Jesse H. Erasmus, Albert J. Auguste   +11 more
doaj   +1 more source

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. [PDF]

, 2019
Febrile illness is a major burden in African children, and non-malarial causes of fever are uncertain. In this retrospective exploratory study, we used metagenomic next-generation sequencing (mNGS) to evaluate serum, nasopharyngeal, and stool specimens ...
Byaruhanga, Oswald, de Bourcy, Charles, DeRisi, Joseph L, Dimitrov, Boris, Egger, Rebecca, Hsu, Jennifer, Juan, Yun-Fang, Kalantar, Katrina, Kyohere, Mary, Langelier, Charles, Mpimbaza, Arthur, Nakielny, Sara, Ramesh, Akshaya, Rosenthal, Philip J, Ruel, Theodore, Sheu, Jonathan, Wang, James, Wilson, Michael R   +17 more
core   +3 more sources

The Role of Temperature in Transmission of Zoonotic Arboviruses

Viruses, 2019
We reviewed the literature on the role of temperature in transmission of zoonotic arboviruses. Vector competence is affected by both direct and indirect effects of temperature, and generally increases with increasing temperature, but results may vary by ...
Alexander T. Ciota, Alexander C. Keyel
doaj   +1 more source

The nonstructural protein NSs of Schmallenberg virus is targeted to the nucleolus and induces nucleolar disorganization [PDF]

, 2016
Schmallenberg virus (SBV) was discovered in Germany in late 2011 and then spread rapidly to many European countries. SBV is an orthobunyavirus that causes abortion and congenital abnormalities in ruminants.
Breard, Emmanuel, Caignard, Grégory, Cochet, Marielle, Coulpier, Muriel, Fablet, Aurore, Gouzil, Julie, Kundlacz, Cindy, Lara, Estelle, Palmarini, Massimo, Sailleau, Corinne, Varela, Mariana, Viarouge, Cyril, Vitour, Damien, Zientara, Stéphan   +13 more
core   +3 more sources

‘Schmallenberg virus’ – a novel orthobunyavirus emerging in Europe

Epidemiology and Infection, 2012
SUMMARYIn 2011, a novel orthobunyavirus of the Simbu serogroup, the Schmallenberg virus (SBV), was discovered using a metagenomic approach. SBV caused a large epidemic in Europe in ruminants. As with related viruses such as Akabane virus, it appears to be transmitted by biting midges.
Beer, M., Conraths, F.J., van der Poel, W.H.M.   +2 more
openaire   +3 more sources

NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery [PDF]

, 2014
Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and ...
Barry, Gerald, Baumgartner, Wolfgang, Blomstrom, Anne-Lie, Caporale, Marco, Hahn, Kerstin, Kohl, Alain, Palmarini, Massimo, Ratinier, Maxime, Schnettler, Esther, Seehusen, Frauke, Varela, Mariana   +10 more
core   +3 more sources

The antiviral RNAi response in vector and non-vector cells against orthobunya viruses [PDF]

, 2017
Background: Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and
Bausch, DG, Blomström, AL, Dietrich, I, Elliott, RM, Kohl, A, McFarlane, M, Schnettler, E, Shi, X, Skelton, JK, Watson, M   +9 more
core   +5 more sources

Shuni Virus in Wildlife and Nonequine Domestic Animals, South Africa

Emerging Infectious Diseases, 2020
We screened nonequine animals with unexplained neurologic signs or death in South Africa during 2010–2018 for Shuni virus (SHUV). SHUV was detected in 3.3% of wildlife, 1.1% of domestic, and 2.0% of avian species.
Jumari Steyn, Pebetsi Motlou, Charmaine van Eeden, Marthi Pretorius, Voula I. Stivaktas, June Williams, Louwtjie P. Snyman, Peter E. Buss, Brianna Beechler, Anna Jolles, Eva Perez-Martin, Jan G. Myburgh, Johan Steyl, Marietjie Venter   +13 more
doaj   +1 more source