Results 201 to 210 of about 981,446 (269)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

open access: yesAdvanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li   +6 more
wiley   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

open access: yesAdvanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li   +9 more
wiley   +1 more source

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

open access: yesAdvanced Science, EarlyView.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones   +5 more
wiley   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

open access: yesAdvanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng   +11 more
wiley   +1 more source

Synergistic Interface Engineering via Buffer Layer and UVO Treatment for High‐Performance PbS Quantum Dot Near‐Infrared Photodiodes

open access: yesAdvanced Science, EarlyView.
A dual‐interface strategy combining a solvent‐orthogonal Poly‐TPD buffer with UV–ozone tuning of PbS‐EDT reconstructs interfacial energetics and defect chemistry in PbS CQD photodiodes. The optimized interface suppresses shunt‐ and trap‐related leakage, reduces noise, and enables high‐detectivity near‐infrared detection with imaging capability ...
Chuan Wei   +8 more
wiley   +1 more source

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