Results 41 to 50 of about 189,105 (268)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Zhongguo dianli, 2020 This paper introduces the configuration of the three-stage cascade exhaust and waste heat utilization system of the direct air cooling unit. In particular, the component structure and working principle of its most critical equipment, i.e., the ...
Zhikun HUANG +5 more
doaj +1 more source
A Rapid Method for the Determination of SBS Content Based on the Principle of Orthogonal Testing
Applied Sciences, 2021 The performance of Styrene-butadiene-styrene (SBS) modified asphalt is closely related to the content of SBS modifier. In the production process of modified asphalt, a certain amount of additive such as sulfur and rubber oil may be added to reduce the ...
Gang Xu +3 more
doaj +1 more source
An orthogonal test of the L -functions Ratios conjecture [PDF]
Proceedings of the London Mathematical Society, 2009 We test the predictions of the L-functions Ratios Conjecture for the family of cuspidal newforms of weight k and level N, with either k fixed and N --> oo through the primes or N=1 and k --> oo. We study the main and lower order terms in the 1-level density. We provide evidence for the Ratios Conjecture by computing and confirming its predictions
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Design and Flow Characteristics of a Gravity-Driven Flow Control Valve
MachinesUltra-high-temperature and pressure downhole environments pose challenges for conventional electronic instruments to adapt to high-temperature formations, thereby restricting the application of downhole electronic tool technology in deep and ultra-deep ...
Qing Wang +11 more
doaj +1 more source
Study on performances and influence factors of mud foam
矿业科学学报, 2019 Spontaneous combustion of coal is a serious threat to the safety production process of coal mine,the traditional technology of coal spontaneous combustion control such as grouting in not good.Mud foam is a new type of fire-fighting material,and the ...
Zhu Hongqing +5 more
doaj +1 more source
Applicable Conditions of Room-and-Pillar Mining Goaf Treatment Methods under a Traffic Load
Applied Sciences, 2023 The disturbance depth of traffic load has a direct impact on the stability of a room-and-pillar mining goaf. To quantitatively calculate the relationship between the traffic load disturbance depth and influencing factors, 49 groups of horizontal ...
Fajin Zu +4 more
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
The use of newly isolated fungal cultures for the selective delignification of bamboo culms
Frontiers in Bioengineering and Biotechnology, 2023 The screening of ligninolytic enzyme-producing fungal species in samples led to the identification of Paracremonium sp. LCB1, Clonostachys compactiuscula LCD1 and C. compactiuscula LCN1.
Bo Zhao +7 more
doaj +1 more source