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Novel models to study Orthohantavirus infection and pathogenesis

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Orthohantavirus Pathogenesis and Cell Tropism [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection in specific reservoir species. Although these viruses mainly circulate among rodents worldwide, spill-over infection to humans occurs. Orthohantavirus infection in humans can result in two distinct clinical outcomes: hemorrhagic fever with renal syndrome (HFRS)
Marco Goeijenbier, Marion Koopmans, Danny Noack   +2 more
exaly   +7 more sources

Phylogeography of Puumala orthohantavirus in Europe [PDF]

Viruses, 2019
Puumala virus is an RNA virus hosted by the bank vole (Myodes glareolus) and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary history is still controversial and so far has not been studied at the whole European level.
Noel Tordo, Alexander Plyusnin, Severine Murri   +2 more
exaly   +9 more sources

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New World's Orthohantavirus

Médecine et Maladies Infectieuses Formation, 2023
Hantavirus infections, whose genus has recently been renamed Orthohantavirus of the Hantaviridae family, are zoonoses transmitted by rodents that cause haemorrhagic fever with renal syndrome (HFRS) in humans in Europe and Asia (Old World Orthohantavirus), or Hantavirus cardiopulmonary syndrome (HPCS) in the Americas (New World Orthohantavirus).
Gourjault, Cyrille, Matheus, Séverine, Le Turnier, Paul, Palich, Romain, Wallet, France, Goehringer, François, Chirouze, Catherine, Kallel, Hatem, Lavergne, Anne, Epelboin, Loïc   +9 more
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Pseudotyped Viruses for Orthohantavirus

2023
Orthohantaviruses, members of the Orthohantavirus genus of Hantaviridae family of the Bunyavirales order, are enveloped, negative-sense, single-stranded, tripartite RNA viruses. They are emerging zoonotic pathogens carried by small mammals including rodents, moles, shrews, and bats and are the etiologic agents of hemorrhagic fever with renal syndrome ...
Tingting, Ning, Weijin, Huang, Li, Min, Yi, Yang, Si, Liu, Junxuan, Xu, Nan, Zhang, Si-An, Xie, Shengtao, Zhu, Youchun, Wang   +9 more
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Prevalence of orthohantavirus in rodents: A systematic review and meta-analysis

Travel Medicine and Infectious Disease, 2023
Orthohantaviruses are zoonotic diseases transmitted mainly by rodents, particularly mice and rats, associated with multiple outbreaks in different continents. Despite its epidemiological relevance, there is a lack of systematic reviews and meta-analyses.To determine the combined global prevalence of Orthohantavirus infection in rodents.A systematic ...
D Katterine Bonilla-Aldana
exaly   +3 more sources

A framework for understanding and predicting orthohantavirus functional traits

Trends in Microbiology, 2023
Orthohantaviruses present a global public health threat; there are 58 distinct viruses currently recognized and case fatality of pathogenic orthohantaviruses ranges from
Nathaniel Mull, Stephanie N. Seifert, Kristian M. Forbes   +2 more
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Identification of a Orthohantavirus strain by clinical metagenomics in Brazil

Diagnostic Microbiology and Infectious Disease
We describe a case of a 33-year-old male presented with fever, myalgia, nausea, and asthenia for six days. The patient lived in a rural area. Initial hypotheses included arbovirus infection, viral hepatitis, and Lyme disease. Reverse transcriptase polymerase chain reaction (RT-PCR) tests for Dengue, Zika, and Chikungunya resulted negative. We were able
Gabriel J, Seara-Morais, Fernando Franco de Oliveira, Miraglia, Jairo Tabacow, Hidal, Luis Fernando Aranha, Camargo, Cristóvão Luis Pitangueira, Mangueira, Andre Mario, Doi, Deyvid Emanuel, Amgarten, Erick Gustavo, Dorlass, Rubia Anita Ferraz, Santana, João Renato Rebello, Pinho   +9 more
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Detection of Anti‐Orthohantavirus Antibodies in Febrile Patients in India

Microbiology and Immunology
ABSTRACT Orthohantaviruses are a genus of zoonotic viruses from the family Hantaviridae, which is primarily known for their ability to cause severe human diseases. The virus is primarily known for causing two major human diseases, hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome.
Sara Chandy, Rohitha S. Chandra, Diksha Sharma, Garima Goyal, Tathagata Das, Ekaterina Martynova, Emmanuel Kabwe, Albert Rizvanov, Svetlana Khaiboullina, Manoj Baranwal   +9 more
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Presence of Andes orthohantavirus in human body fluids

The Lancet Infectious Diseases
Orthohantaviruses belong to emerging zoonotic pathogens of global public health importance that can cause occasional outbreaks, often associated with conflict. 123 These viruses are also categorised as category C pathogens by the US Centers for Disease Control and Prevention, and could be used as biological weapons, with substantial biosafety and ...
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