Results 51 to 60 of about 17,656 (195)

A Sequence‐Based Update on Amino Acid Substitutions in Influenza Polymerase Acidic Protein in Europe That Alter Baloxavir Susceptibility From 2009 to 2025

Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.
ABSTRACT Background Influenza causes 650,000 deaths, 3–5 million hospitalizations, and 1 billion cases worldwide each year. There is a limited repertoire of antivirals available to tackle this burden, highlighting the risk of developing resistance to current drugs.
Alejandro Martín‐Toribio, Inés Inchausti‐Moya, Marina Toquero‐Asensio, Sonia García‐Díaz, Javier Sanchez‐Martinez, Carla Rodriguez‐Crespo, Silvia Galindo‐Carretero, Raquel Iglesia‐Aparicio, Celia Lopez‐Gonzalo, Ana Antón‐Contreras, Silvia Rojo‐Rello, Marta Dominguez‐Gil, Marta Hernández, Jose M. Eiros, Estanislao Nistal‐Villan, Iván Sanz‐Muñoz   +15 more
wiley   +1 more source

Evidence of Influenza A in Wild Norway Rats (Rattus norvegicus) in Boston, Massachusetts

Frontiers in Ecology and Evolution, 2019
Influenza A virus (IAV) is known to circulate among human and animal reservoirs, yet there are few studies that address the potential for urban rodents to carry and shed IAV.
Charles O. Cummings, Nichola J. Hill, Wendy B. Puryear, Benjamin Rogers, Jean Mukherjee, Jessica H. Leibler, Marieke H. Rosenbaum, Jonathan A. Runstadler   +7 more
doaj   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, Volume 13, Issue 31, 4 June 2026.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Lung Microbiome Diversity, Infection Dynamics, and Microbe‐Mediated Cross‐Protection

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The protective role of the lung microbiome in maintaining respiratory health by promoting immune homeostasis, pathogen exclusion, and barrier integrity. Diverse microbial communities regulate immune maturation, enhance epithelial defenses, and contribute to antiviral responses, collectively preventing pathogen colonization and sustaining a balanced ...
Sana Arooj, Akmal Zubair, Syeda Zaira Batool, Granaz Niaz, Muhammad Ali, Yasir Waheed, Eman Ramadan Elsharkawy, Naila Afghan   +7 more
wiley   +1 more source

Virome of Rhipicephalus ticks by metagenomic analysis in Guangdong, southern China

Frontiers in Microbiology, 2022
Tick-borne viruses (TBVs) have increasingly caused a global public health concern. This study collected Rhipicephalus ticks in Guangdong, southern China to identify RNA viruses.
Luanying Guo, Jun Ma, Junwei Lin, Meiyi Chen, Wei Liu, Jin Zha, Qinqin Jin, Hongrong Hong, Weinan Huang, Li Zhang, Ketong Zhang, Zhengkai Wei, Quan Liu, Quan Liu   +13 more
doaj   +1 more source

GTP-bound Human MxA Protein Interacts with the Nucleocapsids of Thogoto Virus (Orthomyxoviridae) [PDF]

Journal of Biological Chemistry, 1999
Human MxA protein is an interferon-induced member of the dynamin superfamily of large GTPases. MxA inhibits the multiplication of several RNA viruses, including Thogoto virus, an influenza virus-like orthomyxovirus transmitted by ticks. Previous studies have indicated that GTP binding is required for antiviral activity, but the mechanism of action is ...
Kochs, Georg, Haller, Otto
openaire   +3 more sources

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.

PLoS Pathogens, 2010
Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the
Benjamin Morin, Bruno Coutard, Michaela Lelke, François Ferron, Romy Kerber, Saïd Jamal, Antoine Frangeul, Cécile Baronti, Rémi Charrel, Xavier de Lamballerie, Clemens Vonrhein, Julien Lescar, Gérard Bricogne, Stephan Günther, Bruno Canard   +14 more
doaj   +1 more source

Sexual Transmission of Arboviruses: A Systematic Review

Viruses, 2020
Arthropod-borne viruses (arboviruses) are primarily maintained in nature in transmission cycles between hematophagous arthropods and vertebrate hosts, but an increasing number of arboviruses have been isolated from or indirectly detected in the ...
Bradley J. Blitvich, Tereza Magalhaes, S. Viridiana Laredo-Tiscareño, Brian D. Foy   +3 more
doaj   +1 more source

Quaranfil, Johnston Atoll, and Lake Chad Viruses Are Novel Members of the Family Orthomyxoviridae [PDF]

Journal of Virology, 2009
ABSTRACT Arboviral infections are an important cause of emerging infections due to the movements of humans, animals, and hematophagous arthropods. Quaranfil virus (QRFV) is an unclassified arbovirus originally isolated from children with mild febrile illness in Quaranfil, Egypt, in 1953.
Rachel M, Presti, Guoyan, Zhao, Wandy L, Beatty, Kathie A, Mihindukulasuriya, Amelia P A Travassos, da Rosa, Vsevolod L, Popov, Robert B, Tesh, Herbert W, Virgin, David, Wang   +8 more
openaire   +2 more sources