Results 71 to 80 of about 22,098 (210)

The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.

PLoS Pathogens, 2010
Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the
Benjamin Morin, Bruno Coutard, Michaela Lelke, François Ferron, Romy Kerber, Saïd Jamal, Antoine Frangeul, Cécile Baronti, Rémi Charrel, Xavier de Lamballerie, Clemens Vonrhein, Julien Lescar, Gérard Bricogne, Stephan Günther, Bruno Canard   +14 more
doaj   +1 more source

Sexual Transmission of Arboviruses: A Systematic Review

Viruses, 2020
Arthropod-borne viruses (arboviruses) are primarily maintained in nature in transmission cycles between hematophagous arthropods and vertebrate hosts, but an increasing number of arboviruses have been isolated from or indirectly detected in the ...
Bradley J. Blitvich, Tereza Magalhaes, S. Viridiana Laredo-Tiscareño, Brian D. Foy   +3 more
doaj   +1 more source

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man, Lin Du, Ying Liu, Zehan Pang, Hongyan Zhu, Bixia Hong, Zhichao Xu, Huahao Fan   +7 more
wiley   +1 more source

Burden of Influenza in Patients Visiting Emergency Department for Treatment of Influenza Like Illness at THQ Hospital Shujabad, Pakistan [PDF]

, 2020
Background: Viral infection of the respiratory tract is a common illness syndrome in humans. Human respiratory tract is infected by large number of viruses. Self-constraining infections are caused by most of them e.g.
Chaudhry, M. (Mamoona), Kaunain, S. A. (Syed), Siftain, A. (Ali), Zaman, M. S. (Muhammad), Zulfiqar, T. (Taiba)   +4 more
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Drivers of Viral Diversity and Sharing in Marine Mammals

Molecular Ecology, Volume 35, Issue 6, March 2026.
ABSTRACT Knowledge of viral infection in marine mammals, a group severely threatened by human activity, is largely limited to the pathology and epidemiology of few endemic viruses. The recent emergence in marine mammals of high‐consequence viruses, such as H5N1 avian influenza and rabies, underscores the importance of understanding the ecology of viral
Matthew J. Arnold, Laura M. Bergner, Haris Malik, Mariel ten Doeschate, Nicholas J. Davison, Andrew Brownlow, Nardus Mollentze, Simon A. Babayan, Daniel G. Streicker   +8 more
wiley   +1 more source

Influenza D Virus Infection in Feral Swine Populations, United States

Emerging Infectious Diseases, 2018
Influenza D virus (IDV) has been identified in domestic cattle, swine, camelid, and small ruminant populations across North America, Europe, Asia, South America, and Africa. Our study investigated seroprevalence and transmissibility of IDV in feral swine.
Lucas Ferguson, Kaijian Luo, Alicia K. Olivier, Fred L. Cunningham, Sherry Blackmon, Katie Hanson-Dorr, Hailiang Sun, John Baroch, Mark W. Lutman, Bianca Quade, William Epperson, Richard Webby, Thomas J. DeLiberto, Xiu-Feng Wan   +13 more
doaj   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family [PDF]

mBio, 2014
ABSTRACT We have recently reported the isolation of a novel virus, provisionally designated C/swine/Oklahoma/1334/2011 (C/OK), with 50% overall homology to human influenza C viruses (ICV), from a pig in Oklahoma. Deep RNA sequencing of C/OK virus found a matrix 1 (M1) protein expression strategy that differed from that of ICV ...
Hause, Ben M., Collin, Emily A., Liu, Runxia, Huang, Bing, Sheng, Zizhang, Lu, Wuxun, Wang, Dan, Nelson, Eric A., Li, Feng   +8 more
openaire   +3 more sources

Clinical Analysis of Neonatal Influenza in the Neonatal Intensive Care Unit: A Retrospective Study

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background To describe the clinical characteristics, treatment, and outcomes of neonatal influenza. Methods Retrospectively analyzed clinical data on 26 neonates who were diagnosed with neonatal influenza by positive influenza nasopharyngeal swab antigen tests, and admitted to the neonatal intensive care unit of Sichuan Province Chengdu ...
Min Zhou, Jia Chen, Jing Zhao, Zhuli Yu, Mengjuan Feng, Xiang Qiu   +5 more
wiley   +1 more source

The role of influenza neuraminidase transmembrane domain on budding and virus morphology [PDF]

, 2014
Influenza A virus neuraminidase (NA), a type II transmembrane glycoprotein plays a role in the cleavage of sialic acids and facilitating the release of mature virions from the surface of infected cells. NA has also previously been shown to play a role in
Roddy, Scott, Edward
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