Targeting the Ubiquitin Proteasome System to Combat Influenza A Virus: Hijacking the Cleanup Crew
ABSTRACT Influenza A virus (IAV) remains a significant global public health threat, causing substantial illness and economic burden. Despite existing antiviral drugs, the emergence of resistant strains necessitates alternative therapeutic strategies.
Vandana Anang+4 more
wiley +1 more source
Liver involvement in severe human influenza A H1N1
Influenza A is a disease caused by a RNA virus, member of the orthomyxoviridae family. The influenza infection is characterized primarily by pulmonary affection that may advance to an acute pulmonary respiratory failure course. Hepatic involvement is not
Raúl Carrillo Esper+4 more
doaj
Extremely premature infants have a higher susceptibility to respiratory virus infections. NEC are critical in defending against respiratory infections. Age‐dependent differences in innate NEC responses to influenza A and RSV were identified, revealing distinct receptor repertoires and antiviral network‐circuits in neonatal versus adult cells.
Lukas Wisgrill+10 more
wiley +1 more source
Influenza: agente etiológico, manifestaciones, diagnóstico, prevención y control
La influenza es una entidad infectocontagiosa causada por un virus cubierto de 80 a 120 nm de diámetro con cápside de simetría helicoidal, que pertenece a la familia Orthomyxoviridae .Ya que todos los subtipos de influenza A existen en aves acuáticas que
Manuel Antonio Vargas Córdoba
doaj
Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier+4 more
wiley +1 more source
Influenza viruses are notorious pathogens that frequently cross the species barrier with often severe consequences for both animal and human health. In 2011, a novel member of the Orthomyxoviridae family, Influenza D virus (IDV), was identified in the ...
Melle Holwerda+6 more
doaj +1 more source
The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?
Influenza virus infection causes severe respiratory illness in people worldwide, disproportionately affecting infants. The immature respiratory tract coupled with the developing immune system, and lack of previous exposure to the virus is thought to ...
Melissa Rioux+6 more
doaj +1 more source
Exploring epigenetic resistance to infectious salmon anaemia in Atlantic salmon by genome-wide bisulfite sequencing in heart tissue [PDF]
The viral disease infectious salmon anaemia (ISA) is an ever-present threat to salmon farmers globally. Since its appearance it has been responsible for crises in the industry and has changed the way in which salmon are farmed.
Ekvall, Hans
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Soybean extract inhibits influenza virus entry: Mechanistic insights
Our study revealed an effect on entry within the antiviral properties of soybean extract. We found that the inhibition of viral entry by soybean extract was an inhibition of clathrin‐dependent endocytosis. Abstract Influenza viruses pose significant public health threats because they can cause seasonal outbreaks and global pandemics. Current preventive
Natsumi Sakata+3 more
wiley +1 more source
Tissue tropism and optimization and evaluation of diagnostics test for the detection of Pilchard orthomyxovirus (POMV) in Atlantic salmon (Salmo salar) [PDF]
Since 2012, pilchard orthomyxovirus (POMV) has been of major concern to the Tasmanian salmonid industry. The virus was first discovered in pilchards, and is, so far, only shown to be highly infectious to Atlantic salmon (Salmo salar).
Tengesdal, Hedda Kjølleberg
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