Results 91 to 100 of about 2,259,114 (308)

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

“I am trapped in my body”: a qualitative exploration of bodily experiences during brace treatment among adolescents with idiopathic scoliosis

International Journal of Qualitative Studies on Health & Well-Being
Purpose Adolescent idiopathic scoliosis (AIS) is a spinal deformity that often requires long-term bracing to prevent the progression of spinal curvature. However, bracing impacts several aspects of adolescents’ lives.
Marit Fure, Kristine Risum, Lena Fauske, Hedda Eik   +3 more
doaj   +1 more source

WISP-1 drives bone formation at the expense of fat formation in human perivascular stem cells

Scientific Reports, 2018
The vascular wall within adipose tissue is a source of mesenchymal progenitors, referred to as perivascular stem/stromal cells (PSC). PSC are isolated via fluorescence activated cell sorting (FACS), and defined as a bipartite population of pericytes and ...
Carolyn A. Meyers, Jiajia Xu, Greg Asatrian, Catherine Ding, Jia Shen, Kristen Broderick, Kang Ting, Chia Soo, Bruno Peault, Aaron W. James   +9 more
doaj   +1 more source

The use of three-dimensional printing technology in orthopaedic surgery: A review [PDF]

, 2017
Three-dimensional (3-D) printing or additive manufacturing, an advanced technology that 3-D physical models are created, has been wildly applied in medical industries, including cardiothoracic surgery, cranio-maxillo-facial surgery and orthopaedic ...
Wong, TM, Lau, TW, Yeung, KWK, To, MKT, Jin, JIMMY, Yan, CH, Leung, FKL, Fang, CX   +7 more
core   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Integrating Learning And Visualization Technologies In Orthopaedics:- Establishing The Virtual Orthopaedic European University

, 2002
Digital technologies offer a working environment for familiarisation with new surgical procedures and management of clinical case audit. Our aim is to provide a novel route for access to educational material that more closely resembles the working ...
Campbell, N, Wills, G, Grange, S, Bunker, T, Setchell, C   +4 more
core   +1 more source

Glosso - Pharyngeal Breathing

South African Journal of Physiotherapy, 1958
No abstract available.
Margaret P. Baker
doaj   +1 more source

The impact of clostridium difficile infection in orthopaedic patients

, 1995
Journal of Orthopaedic Surgery3257 ...
Thiagarajan, P., McCreath, S.W.
core  

Subspecialization in the Field of Orthopaedic Surgery [PDF]

, 2015
Background: Subspecialization within the various specialties of medicine is on the rise in the world. The orthopaedic community is experiencing the same with academic centers tending to develop subspecialty practices in the developing world.Objectives ...
Muteti, EN
core   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source