Results 51 to 60 of about 39,132 (298)

Is 5 the New 25? Long-Term Oncologic Outcomes From a Phase II, Prospective, 5-Fraction Preoperative Radiation Therapy Trial in Patients With Localized Soft Tissue Sarcoma

Advances in Radiation Oncology, 2022
Purpose: Management of adult soft tissue sarcomas entails a multidisciplinary approach with surgery and radiation therapy with or without chemotherapy. The use of preoperative irradiation has been well established, and although conventional fractionation
Meena Bedi, MD, Reena Singh, MD, John A. Charlson, MD, Tracy Kelly, MD, Candice Johnstone, MD, MPH, Adam Wooldridge, MD, MPH, Donald A. Hackbarth, MD, Nicole Moore, BS, CCRP, John C. Neilson, MD, David M. King, MD   +9 more
doaj   +1 more source

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

Upfront surgical resection for primary bone tumors: rationale and potential benefits

Surgical and Experimental Pathology, 2020
Local control for the treatment of primary bone tumors is generally delayed following neoadjuvant chemotherapy. This was born out of the historical need to manufacture custom implants when performing limb-salvage resection.
Yoav S. Zvi, Amit Singla, Alexander J. Chou, Janet Tingling, Rui Yang, Bang H. Hoang, David S. Geller   +6 more
doaj   +1 more source

A chronicle review of new techniques that facilitate the understanding and development of optimal individualized therapeutic strategies for chordoma

Frontiers in Oncology, 2022
Chordoma is a rare malignant bone tumor that mainly occurs in the sacrum and the clivus/skull base. Surgical resection is the treatment of choice for chordoma, but the local recurrence rate is high with unsatisfactory prognosis.
Chenglong Zhao, Tao Tan, E. Zhang, Ting Wang, Haiyi Gong, Qi Jia, Tielong Liu, Xinghai Yang, Jian Zhao, Zhipeng Wu, Haifeng Wei, Jianru Xiao, Cheng Yang   +12 more
doaj   +1 more source

Increased Rates of Prolonged Length of Stay, Readmissions, and Discharge to Care Facilities among Postoperative Patients with Disseminated Malignancy: Implications for Clinical Practice. [PDF]

, 2016
BackgroundThe impact of surgery on end of life care for patients with disseminated malignancy (DMa) is incompletely characterized. The purpose of this study was to evaluate postoperative outcomes impacting quality of care among DMa patients, specifically
Bateni, Sarah B, Bold, Richard J, Canter, Robert J, Meyers, Frederick J   +3 more
core   +2 more sources

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Nationwide Real‐World Modeling of Surgical Outcomes in Elderly Patients: Incorporating Geriatric‐Specific Risk Factors Into Prediction of Mortality and Morbidity

Annals of Gastroenterological Surgery, EarlyView.
A reliable and effective risk prediction model for mortality and morbidity in elderly patients undergoing gastroenterological surgeries was developed and validated. Geriatric‐specific risk factors, including the newly added variables in the NCD registry, along with age, were identified as significant contributors to the model. ABSTRACT Aim As the aging
Naoya Sato, Hiraku Kumamaru, Mitsukazu Gotoh, Yoshihiro Kakeji, Yuko Kitagawa, Yasuyuki Seto, Hiromi Rakugi, Masahiro Akishita, Kazue Nakajima, Arata Takahashi, Hiroaki Miyata, Shigeru Marubashi   +11 more
wiley   +1 more source

2016 Physicians Assistant Licensure Survey Instrument [PDF]

, 2019
In 2016 all Physician Assistants who biennially renewed their license electronically were invited to complete this voluntary Survey Instrument administered by the Indiana Professional Licensing Agency (IPLA).
Maxey, Hannah, Randolph, Courtney
core  

Chordoma. Clinical characteristics, management and prognosis of a case series of 25 patients [PDF]

, 2010
Background: Adequate surgery still remains the only curative treatment of chordoma. Interesting clinical data on advanced disease with molecularly targeted therapies were reported.Methods: We described the clinical outcome of a series of chordoma ...
Virginia Ferraresi, Carmen Nuzzo, Carmine Zoccali, Ferdinando Marandino, Antonello Vidiri, Nicola Salducca, Massimo Zeuli, Diana Giannarelli, Francesco Cognetti, Roberto Biagini, A Jemal, R Chugh, CE Peña, JM Mirra, NL Higinbotham, C Catton, PW Chambers, S Boriani, F Tzortzidis, D Baratti, D Schulz-Ertner, DC Weber, GF Fleming, E Tamborini, S Stacchiotti, H Hof, K Schönegger, ZL Gokaslan, HY Zhang, P Bergh, KL Foweraker, PA Forsyth, BJ Cummings, P Gabriele, GC Feigl, HD Suit, M Austin-Seymour, M Austin-Seymour, G Noël, R Chugh, PG Scimeca, A Azzarelli, PG Casali, PG Casali, PM Weinberger, S Stacchiotti   +45 more
core   +1 more source

Rising Pancreatic Cancer Incidence in Young Japanese Women and Increasing Distal Pancreatectomy in Older Adults: A Nationwide Claims‐Based Analysis From 2016 to 2023

Annals of Gastroenterological Surgery, EarlyView.
This nationwide claims‐based study analyzed recent trends in pancreatic cancer incidence (2016–2021) and surgery (2016–2023) in Japan. The study revealed a rising incidence of pancreatic cancer, notably among young women, and an increasing use of distal pancreatectomy among older adults.
Masamitsu Kido, Ryo Morimura, Yusuke Yamamoto, Tomohiro Arita, Shingo Nakashima, Katsutoshi Shoda, Taisuke Imamura, Hidemasa Kubo, Kengo Yoshii, Iichiroh Onishi, Atsushi Shiozaki   +10 more
wiley   +1 more source