Results 141 to 150 of about 95,083 (274)

DNA Origami‐Based CD44‐Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv   +8 more
wiley   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

open access: yesAdvanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong   +12 more
wiley   +1 more source

Needling Procedures for Calcific Tendinitis Performed by Orthopedic Surgeons

open access: diamond, 2017
Chae Hyun Pang   +4 more
openalex   +2 more sources

Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy

open access: yesAdvanced Science, EarlyView.
Patients with osteoporosis face a higher risk of bone injury, mainly due to weakened osteogenic differentiation and bone formation, along with increased osteoclast differentiation and bone resorption activity, leading to bone homeostasis imbalance.
Xinhui Wu   +13 more
wiley   +1 more source

Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration

open access: yesAdvanced Science, EarlyView.
The supramolecular lubricating hydrogel microspheres can provide stable mechanophysical protection at damaged matrix through interfacial hydration lubrication: in the early and middle stages, microspheres can actively provide microscale supramolecular lubrication (µ ≈ 0.04) for damaged matrix; in the late stage, the wear debris induced by shear and ...
Hui Yuan   +3 more
wiley   +1 more source

Venous thromboembolism (VTE) prevention in orthopedics: facts, controversies, and evolving management

open access: yesOrthopedic Research and Reviews, 2012
Jessica M Langer,1 Alpesh Amin21Department of Medicine, University of California, Irvine, Irvine, CA, USA; 2University of California, Irvine Medical Center, Orange, CA, USAAbstract: Multiple orthopedic procedures are performed each year including knee ...
Langer JM, Amin A
doaj  

Dynamic Bonds Reinforced Polyamide Elastomer for Biomedical Orthosis

open access: yesAdvanced Science, EarlyView.
A dynamic bonds (DBs) reinforced shape memory polyamide elastomer is developed using reactive extrusion. Dynamic covalent networks enhance interlayer adhesion in 4D‐printed objects by utilizing the combined effects of multiple DBs, reducing mechanical anisotropy and improving the mechanical and shape memory properties.
Zhen Li   +12 more
wiley   +1 more source

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