Results 121 to 130 of about 1,808,393 (288)

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

A Multimodal Protocol to Diminish Pain Following Common Orthopedic Sports Procedures: Can We Eliminate Postoperative Opioids?

, 2020
PURPOSE: To determine if postsurgical pain, measured by visual analogue scale (VAS), following common orthopedic sports procedures could be managed effectively with a nonopioid multimodal analgesic protocol.
Schwartz, Kaylin, Moutzouros, Vasilios, Jildeh, Toufic R, Hasan, Laith, Khalil, Lafi S, Matar, Robert N, Okoroha, Kelechi R   +6 more
core   +1 more source

Efficacy of tranexamic acid for prevention of heterotopic ossification after orthopedic surgery: a systematic review and meta-analysis

BMC Surgery
Background To systematically evaluate the effect of tranexamic acid (TXA) on the incidence of heterotopic ossification (HO) following orthopedic surgery. Methods A Systematic review and Meta-analysis was carried out according to PRISMA guidelines. PubMed,
Xingui Wang, Di Guo, Xiaoguang Xu, Zhitao Wang, Bo Lv, Yonghai Lou   +5 more
doaj   +1 more source

Orthopedic Bone Drill

This project aims to design a bone drill for orthopedic procedures which alleviates the heat generated in the bone during ...
Geng, May, Schmid, Logan G, Wold, Matthew T   +2 more
core  

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

ORTHOPEDIC NURSING PROCEDURES

AJN, American Journal of Nursing, 1970
Elizabeth D. Joseph, Avice Kerr
openaire   +3 more sources

Results of the Ponseti method after congenital clubfoot recurrence subjected to posteromedial release: A retrospective study of 57 feet

Journal of the Foot & Ankle
Introduction: The treatment of congenital clubfoot (CCF) relied on corrective surgeries, such as posteromedial release, as the method of choice, especially in cases of recurrence.
Elizabeth de Alvarenga Borges da Fonsêca, Monica Paschoal Nogueira   +1 more
doaj   +1 more source

Bleeding management in elective orthopedic surgery

, 2014
Preoperative anemia and blood loss are two major concerns in elective orthopedic surgery. Most orthopedic surgeons consider allogenic blood transfusions to be a standard treatment in cases of low hemoglobin, although a number of well-recognized risks and
Theusinger, Oliver M, Oliver M. Theusinger   +1 more
core   +1 more source

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

Advanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu, Ziqian Yang, Arina E. Velieva, Eleanor M. Plaster, Mingyue Fan, Donia W. Ahmed, Avinava Roy, Pamela Duran, Pamela Panovich, Alexandra S. Piotrowski‐Daspit, Carlos A. Aguilar, Megan L. Killian, Claudia Loebel   +12 more
wiley   +1 more source

Risk Factors for Opioid-Related Adverse Drug Events Among Older Adults After Hospitalization for Major Orthopedic Procedures. [PDF]

J Patient Saf, 2023
Herzig SJ, Anderson TS, Urman RD, Jung Y, Ngo LH, McCarthy EP.   +5 more
europepmc   +1 more source