Results 111 to 120 of about 1,615,771 (249)

Treatment trends for acquired hallux valgus among orthopedic surgeons and podiatrists

Foot & Ankle Orthopaedics, 2018
Category: Bunion Introduction/Purpose: Foot and ankle surgery is unique in that both orthopedic surgeons and podiatrists perform many of the same procedures.
Ryan Callahan DO, MS, Umur Aydogan MD, Guodong Liu, Djibril Ba   +3 more
doaj   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Efficacy of tranexamic acid for prevention of heterotopic ossification after orthopedic surgery: a systematic review and meta-analysis

BMC Surgery
Background To systematically evaluate the effect of tranexamic acid (TXA) on the incidence of heterotopic ossification (HO) following orthopedic surgery. Methods A Systematic review and Meta-analysis was carried out according to PRISMA guidelines. PubMed,
Xingui Wang, Di Guo, Xiaoguang Xu, Zhitao Wang, Bo Lv, Yonghai Lou   +5 more
doaj   +1 more source

Antibacterial properties of PEKK for orthopedic applications

, 2017
Mian Wang,1 Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, People’s Republic of China ...
Wang M, Bhardwaj G, Webster TJ
core  

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Use of X-ray fluoroscopy in orthopedic operations: The patient’s perspective

, 2009
Zain Ul-Abadin1, Faisal rauf Khan2, Shams Rauf3, Nadia Rauf31Blackpool Victoria Hospital, Blackpool, UK; 2Ysbyty Gwynedd, Bangor, North West Wales, UK; 3Gynaecology LRH, Peshawar, PakistanAbstract: We collected data from 50 patients who had orthopedic ...
Zain Ul-Abadin, Shams Rauf, Nadia Rauf, Faisal rauf Khan   +3 more
core  

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

Advanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang, Ke Ma, Kangqing Zuo, Pandong Lin, Tailong Zhang, Rongliang Ding, Linbo Zhang, Aonan Li, Yinchuan Wang, Yanling Huang, Jichao Feng, Guiyong Xiao, Yupeng Lu, Bing Han, Zhiqiang Wang, Ningbo Li   +15 more
wiley   +1 more source

Results of the Ponseti method after congenital clubfoot recurrence subjected to posteromedial release: A retrospective study of 57 feet

Journal of the Foot & Ankle
Introduction: The treatment of congenital clubfoot (CCF) relied on corrective surgeries, such as posteromedial release, as the method of choice, especially in cases of recurrence.
Elizabeth de Alvarenga Borges da Fonsêca, Monica Paschoal Nogueira   +1 more
doaj   +1 more source