Results 91 to 100 of about 1,808,393 (288)

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Clinical implications and costs of in-hospital versus outpatient orthopedic surgeries

Journal of the Foot & Ankle
Objective: This article reviews clinical implications and costs associated with orthopedic surgeries performed in inpatient versus outpatient settings.
Luciana Fontes De Marco, Ana Fabricia Feitosa Dias, Manuel Fernando Colares De Souza Vasconcelos, Lucas Viana Pagotti, Raphael Andrade Oliveira, Odair Sebastião Barboza Da Silva Junior   +5 more
doaj   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

ARTHROSCOPIC LATARJET WITH CORTICAL BUTTONS: CLINICAL AND RADIOLOGICAL OUTCOMES [PDF]

Acta Ortopédica Brasileira
Objective: To evaluate clinical and radiological outcomes of the arthroscopic Latarjet procedure with cortical buttons for traumatic anterior shoulder instability.
Alexandre Tadeu do Nascimento, Caio Santos Checchia, Jorge Henrique Assunção, Mauro Emilio Conforto Gracitelli, Fernando Brandão de Andrade e Silva, Robson Massi Bastos, Arnaldo Amado Ferreira Neto, Eduardo Angeli Malavolta   +7 more
doaj   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Readmission from orthopedic surgical site infections: an integrative review

, 2015
OBJECTIVE Characterizing readmissions from orthopedic surgical site infections. METHOD An integrative review of literature in the LILACS, IBECS, MEDLINE, Cochrane, SciELO and PUBMED databases, using the descriptors Patient readmission, Wound infection ...
Arménio Guardado Cruz, Turrini, Ruth Natália Teresa, Miriam Aparecida Barbosa Merighi, Torres, Lilian Machado, Merighi, Miriam Aparecida Barbosa, Ruth Natália Teresa Turrini, Cruz, Arménio Guardado, Lilian Machado Torres   +7 more
core   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Differences in Postoperative Outcomes of Common Foot and Ankle Procedures Performed by Orthopedic Surgeons and Podiatrists

Foot & Ankle Orthopaedics
Category: Ankle; Midfoot/Forefoot Introduction/Purpose: In the United States, there has been a substantial rise in podiatrists to address the increasing prevalence of foot and ankle pathologies.
Myra S. Chao BA, Kevin Yunhao Heo BS, Michelle M. Coleman MD, PhD, Gregory P. Guyton MD   +3 more
doaj   +1 more source

Distribution and Cost Profile of Orthopedic Surgical Services at a Rural Province Hospital in Nepal: An Observational Study

Journal of Nepal Medical Association
Introduction: Musculoskeletal conditions are an important cause of disability in Nepal, particularly in rural settings where financial and structural constraints limit timely access to orthopedic surgical care.
Siddhartha Khanal, • Shankar Sigdel, Suman Subedi, Shambhu Adhikari, Ripu Singh, Sagun Khanal, Sailendra Bista, Sandesh Shrestha   +7 more
doaj   +1 more source

ECONOMIC AND CLINICAL IMPACT OF LONG WAITING LISTS FOR SCOLIOSIS SURGERY [PDF]

Coluna/Columna
Objectives: To evaluate the implications of waiting lists for Adolescent Idiopathic Scoliosis (AIS) surgery in the Unified Health System (SUS), from the perspective of managers and physicians, and to propose cost-effective solutions.
Juliana Barbosa Goulardins, Carolina Villa Nova Aguiar, Cristiane Maria Carvalho Costa Dias, Robert Meves, Andre Luis Fernandes Andújar, Marcos Almeida Matos   +5 more
doaj   +1 more source