Results 141 to 150 of about 127,817 (292)
Advanced Science, EarlyView.A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang +14 more
wiley +1 more source
Advanced Science, EarlyView.A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang +12 more
wiley +1 more source
Advanced Science, EarlyView.Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai +16 more
wiley +1 more source
Integration of operating room planning and scheduling through managing uncertainty for emergency patients in orthopedic surgery [PDF]
, 2014 Today, Health care management is becoming increasingly important for patients in hospitals. Hospital managers want to increase patient satisfaction and hospital’s efficiency, particularly in Operating Rooms (OR).
Deljoumanesh, Hassan
core
Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency Department [PDF]
Background: Orthopedic procedures are one of the most common medical procedures in the Emergency Department (ED) and are also among the most painful procedures performed on the conscious patient.
Mani Mofidi +7 more
core +1 more source
Quality of Life After Orthopedic Procedures at Buraydah Central Hospital and King Fahad Specialist Hospital in Qassim Region, Saudi Arabia. [PDF]
Cureus, 2022 Alharbi M +8 more
europepmc +1 more source
Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury
Advanced Science, EarlyView.After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez +8 more
wiley +1 more source
Study to estimate the average blood loss in different orthopedic procedures: A retrospective review. [PDF]
Ann Med Surg (Lond), 2021 Hasan Khan MN +5 more
europepmc +1 more source
Annals of Gastroenterological Surgery, EarlyView.This study analyzed nationwide trends, demographic characteristics, and seasonal patterns of rectal prolapse surgery in Japan using healthcare claims data. From 2014 to 2023, age‐adjusted overall and conventional surgeries declined significantly, whereas laparoscopic surgeries increased significantly.
Masamitsu Kido +9 more
wiley +1 more source