Results 151 to 160 of about 95,083 (274)

Clean Cut (adaptive, multimodal surgical infection prevention programme) for low‐resource settings: a prospective quality improvement study

BJS (British Journal of Surgery), EarlyView., 2020
Clean Cut is a multimodal, adaptive, checklist‐based infection prevention programme designed to improve compliance with six critical perioperative infection prevention practices. After introducing the programme at five hospitals in Ethiopia, compliance with critical infection prevention standards significantly improved and the relative risk of ...
J. A. Forrester, N. Starr, T. Negussie, D. Schaps, M. Adem, S. Alemu, D. Amenu, N. Gebeyehu, T. Habteyohannes, F. Jiru, A. Tesfaye, E. Wayessa, R. Chen, A. Trickey, S. Bitew, A. Bekele, T. G. Weiser   +16 more
wiley   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source

Barriers to Performing Soft Tissue Reconstruction Procedures among Orthopedic Surgeons in Low- and Middle-income Countries: Results of a Surgical Skills Training Course

, 2019
Jordan T. Holler, Patrick Albright, Sravya Challa, Syed H. Ali, Deborah B. Martins, Kari A. Keys, David Shearer, Michael J. Terry   +7 more
openalex   +1 more source

Can We Eliminate Opioids After Common Orthopedic Sports Procedures? A Novel Multimodal Pain Protocol [PDF]

, 2021
Toufic R. Jildeh, Vasilios Moutzouros, Lafi S. Khalil, Kaylin Schwartz, Laith K. Hasan, Robert N. Matar, Joseph S. Tramer, Kelechi R. Okoroha   +7 more
openalex   +1 more source

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

Advanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong, Hanwen Gu, Yuanqiang Zhang, Qunbo Meng, Qi Li, Kangle Song, Yanlin Li, Kaiwen Liu, Zhenchuan Liu, Rui Hu, Haoxi Zhai, Tian Li, Zemin Ling, Zhijian Wei, Fuxin Wei, Lei Cheng   +15 more
wiley   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

An Osteoconductive Janus Hydrogel with Full Barrier Protection and Adaptable Degradation Properties for Superior Bone Regeneration

Advanced Science, EarlyView.
The filler‐barrier hydrogel system developed by dual‐network Janus structural strategy breaks through the difficulty of a single hydrogel to combine barrier protection with bone regeneration, and realizes the regeneration‐material degradation adaptation for the field of mandibular regeneration.
Yanhui Lu, Jia Song, Yongle Lv, Boon Chin Heng, Mingming Xu, Ying He, Youde Liang, Lu‐Ning Wang, Tingting Wu, Ting Song, Tingjun Li, Qiaomei Ren, Lei Wang, Xuliang Deng, Xuehui Zhang   +14 more
wiley   +1 more source

Regional Anesthesia for Pain Management After Orthopedic Procedures for Treatment of Lower Extremity Length Discrepancy. [PDF]

J Pain Res, 2020
Arce Villalobos M, Veneziano G, Iobst C, Miller R, Walch AG, Roth C, Argote-Romero G, Martin DP, Beltran RJ, Tobias JD.   +9 more
europepmc   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Injectable bone cement based on magnesium potassium phosphate and cross-linked alginate hydrogel designed for minimally invasive orthopedic procedures. [PDF]

Sci Rep
Wekwejt M, Jesiołkiewicz R, Mielewczyk-Gryń A, Kozień D, Ronowska A, Kozłowska J, Gbureck U.   +6 more
europepmc   +1 more source