Results 51 to 60 of about 28,113 (250)
Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims
Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld +9 morewiley +1 more sourceNondipping in Parkinson's Disease
Parkinson's Disease, 2011 Objective. The aim of this study was to identify patients with Parkinson's disease who showed loss or decrease of nocturnal blood pressure fall (nondipper patients) as a marker of autonomic dysfunction.Sita Sommer, Billur Aral-Becher, Wolfgang Jost +2 moredoaj +1 more sourceOrthostatic Cerebral Hypoperfusion Syndrome (OCHOS)
Frontiers in Aging Neuroscience, 2016 Objective: Orthostatic dizziness without orthostatic hypotension is common but underlying pathophysiology is poorly understood. This study describes orthostatic cerebral hypoperfusion syndrome (OCHOS). OCHOS is defined by: 1) Abnormal orthostatic drop of Peter eNovakdoaj +1 more sourceSafety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study
Clinical Pharmacology in Drug Development, EarlyView.Abstract
Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye +7 morewiley +1 more sourceA phenomap of TTR amyloidosis to aid diagnostic screening
ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.Abstract
Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos +4 morewiley +1 more sourceSubcutaneous Apomorphine Infusion Initiation Is Associated with Impulse Control Disorder Attenuation in Advanced Parkinson's Disease Patients: Insights from the French NS‐Park Cohort
Movement Disorders Clinical Practice, EarlyView.Abstract Background
Impulse control disorders (ICD) are common non‐motor complications in Parkinson's disease (PD), particularly in patients receiving oral dopamine agonists (DA). Continuous subcutaneous apomorphine infusion (CSAI) is a device‐aided therapy for advanced PD, but its effects on ICD remain underexplored in real‐world settings.Clément Desjardins, Paulo André Dias Bastos, Aymeric Lanore, Christine Brefel‐Courbon, Isabelle Benatru, Caroline Giordana, Anne Doe de Maindreville, Giovanni Castelnovo, Philippe Remy, Luc Defebvre, Claire Thiriez, Stéphane Prange, Jean‐Luc Houeto, Alexandra Samier Foubert, Fabienne Ory‐Magne, Raquel Pinhero Barbosa, Nathalie Bertille, Jean‐Christophe Corvol, Olivier Rascol, Margherita Fabbri, on behalf of the NS‐Part Cohort study group, Jean‐Christophe Corvol, Olivier Rascol, Margherita Fabbri, Wassilios Meissner, Stéphane Thobois, Luc Defebvre, Helene Esperou, Florence Tubach, Yann De Rycke, Layidé Roufai, Dalila Ouazib, Sandra Zarrad, Fatma Khelifi, Florence Tubach, Yann De Rycke, Nathalie Bertille, Vanessa Rousseau, Samuel Tessier, Margherita Fabbri, David Tavel, Dounya Metdaoui, Avigaelle Abitbol, Mathias Antunes, Alexis Brice, Suzanne Lesage, Christelle Tessson, Fanny Casse, Mélanie Ferrien, Guillaume Cogan, Lisa Welment, Thierry Moulin, Wassilios Meissner, Claire Thiriez, Stéphane Thobois, Christian Geny, Solène Frismand, Anne‐Gaëlle Corbille, Caroline Giordana, Giovanni Castelnovo, Isabelle Benatru, Sophie Drapier, David Maltete, Christine Tranchant, Olivier Rascol, Mickael Aubignat, Marie Mongin, Matthieu Bereau, Alexandra Foubert‐Samier, Brice Laurens, Sylvain Vergnet, Thomas Boraud, David Bendetowicz, Jade Sarrabere, Dominique Guehl, Pierre Burbaud, Paul‐Alexandre Pfeiffer, Gilles Defer, Bérengère Debilly, Philippe Derost, Alice Dormeuil, Aimée Petit, Alban Gravier, Vincent Schneider, Lucie Garnier, Nicolas Carriere, Olivier Colin, Philippe Couratier, Chloé Laurencin, Stephane Prange, Paul Jaulent, Bruno Plus, Helene Gervais‐Bernard, Alexandre Eusebio, Frédérique Fluchere, Stephan Grimaldi, Valentin Mira, Tatiana Witjas, Mahmoud Charif, Ophelie Forster, Alix Durand, Pauline Prin, Lucie Hopes, Amory Jardel, Salome Puisieux, Guillemette Clement, Philippe Damier, Tiphaine Rouaud, Pascal Derkinderen, Arthur Lionnet, Adrien De Guilhem De Lataillade, Cosmin Alecu, Charlotte Heraud, Marie De Verdal, Graziella Mangone, Sara Sambin, Aymeric Lanore, Thomas Courtin, Louise‐Laure Mariani, Fouad Khoury, Poornima Menon, Florence Cormier‐Dequaire, Emmanuel Flamand‐Roze, David Grabli, Elodie Hainque, Marie Vidhaillet, Aurélie Meneret, Cécile Delorme, Cendrine Foucard, Florian Von Raison, Alexis Elbaz, Andreas Hartmann, Vincent Leclercq, Theodore Soulier, Daniel Torres, Giulia Coarelli, Giorgia Querin, Fabien Hauw, Margaux Dunoyer, Solène Ansquer, Frederique Leh, Marion Leclercq, Simon Lamy, Guillaume Carey, Guillaume Costentin, Clemence Hardy, Mathieu Anheim, Ouhaid Lagha Boukbiza, Thomas Wirth, Jimmy Voirin, Marie Des Neiges Santin, Thomas Bogdan, Margherita Fabbri, Christine Brefel Courbon Ory‐Magne, Clemence Leung, Hélène Catala, Gabrielle Sill, Raquel Pinheiro Barbosa, Lucy Famer, Lucie Braccagni, Hiba Sifaoui, Juliette Palisson, Kenza Benrahmoune Idrissi, Astrid Causel, Lydie Romeo, Constance Bissessur, Audace Cure‐Martin, Charline Compagne, Sandrine Dupouy, Sandrine Villars, Wei‐Ho Lai, Rachida Bari, Damien Chevanne, Elodie Durand, Isabelle Rieu, Stephane Bernard, Corinne Garsault, Nathalie Meunier, Alexia Cresson, Marine Sgard, Marie Dreano, Justine Montillot, Renaud Massart, Pascale Grebent, Pierre Pelissier, Valérie Santraine, Thomas Gaudin, Pierre Boutet, Cécile Thuilier, Coralie Chalot, Céline Prevost, Hélène Videaud, Justine Picut, Christian Tarrade, Catherine Caire, Hélène Merle, Elise Metereau, Mathilde Millot, Chloe Bernardi, Emilie Favre, Adelaide Jaulent, Laura Mundler, Blandine Dufresne, Eve Benchetrit, Valérie Driss, Alexia Arifi, Maura Rodrigues, Lili Le Monnier, Nathalie Dumont, Virginie Bablon, Régis Frenais, Caroline Herve, Christelle Guimber, Vanessa Ferrier, Elodie David, Christina Faroul, Leslie Fra, Elsa Foucaran, Fatima‐Ezzahra Ennaji, Jeremy Bonetto, Ryad Ladghem‐Chikouche, Le Mickael, Sophie Liot, Sonia Messar, Hamza Salah, Amelie Bernardo, Naoual Serari, Emilie Rabois, Carole David, Zoe Fournier, Margaux Bonnaire‐Verdier, Elise Chevaillier, Françoise Kestens, Rozenn Gourhan, Sandra Lopez‐Alfaro, Jean‐François Houvenaghel, Mélanie Alexandre, Christine Bourdonnais, Linda Vernon, Ahmed Boumediene, Hugo Rummel, Céline Julie, Nadine Longato, Célie Phillipps, Anne Claire Andries‐Ros, Stéphanie Bras, Estelle Harroch, Claudia Gillet, Yoan Herades, Eva Camgrand +249 morewiley +1 more source
