Results 71 to 80 of about 25,925 (236)

Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe, Sergio García‐Díaz, Laura Muñoz‐Delgado, Miguel Martín‐Bórnez, Silvia Jesús, Dolores Buiza‐Rueda, Marta Bonilla‐Toribio, Rafael Díaz‐Belloso, Daniel Macías‐García, Astrid Adarmes‐Gómez, Antonio Luque‐Ambrosiani, Rocío Pineda‐Sánchez, Lorena Clavijo‐Jiménez, Fátima Carrillo‐García, Pilar Gómez‐Garre, Pablo Mir   +15 more
wiley   +1 more source

Variants and role of hypotension in heart failure: rationale and design of an additional study of ORTHO-HYPO within the CARMEN-CHF program

Кардиоваскулярная терапия и профилактика
As part of the observational, multicenter prospective study CardioReno-Hepato-Metabolic Disease in Chronic Heart Failure (CARMENCHF), an additional exploratory study of the types and role of hypotension in heart failure (ORTHO-HYPO) was specifically ...
A. E. Solovyova, Yu. I. Begrambekova, N. I. Novitsky, E. A. Kuzheleva, A. N. Baglikov, Yu. V. Mareev, A. A. Shchendrygina, V. A. Safronenko, V. V. Skibitsky, A. V. Fendrikova, M. A. Teterina, A. Yu. Gorshkov, S. S. Yakushin, A. A. Garganeeva, A. I. Chesnikova, F. T. Ageev, O. M. Drapkina, V. Yu. Mareev   +17 more
doaj   +1 more source

Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease

Scientific Reports, 2017
We aimed to explore the effects of bilateral subthalamic nucleus stimulation and levodopa on cardiovascular autonomic function in Parkinson’s disease.
Kai Li, Rocco Haase, Heinz Rüdiger, Manja Reimann, Heinz Reichmann, Martin Wolz, Tjalf Ziemssen   +6 more
doaj   +1 more source

Evaluation of orthostatic dizziness and lightheadedness in older adults: symptoms not to be taken lightly

Frontiers in Neurology
Orthostatic dizziness and lightheadedness are frequent complaints in patients age 60 and above, whereas various common and uncommon etiologies need to be considered, including medication side effects, cardiovascular and metabolic causes and neurologic ...
Svetlana Blitshteyn, Svetlana Blitshteyn
doaj   +1 more source

Diagnostic Value of Glycocalyx Shedding in Blood for Differentiating between Parkinson's Disease and Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Blood–brain barrier disruption is increasingly recognized in synucleinopathies, but the role of the endothelial glycocalyx (GLX) in Parkinson's disease (PD) and multiple system atrophy (MSA) remains unclear. Objectives The aim was to determine whether plasma GLX markers differ between PD, MSA, and healthy controls (HC), relate to ...
Jonas Folke, Brian DellaValle, Mathias Lindh Jørgensen, Phillip Bredahl Mogensen, Casper Hempel, Jørgen Rungby, Anne‐Mette Hejl, Annemette Løkkegaard, Lisette Salvesen, Sara Bech, Mette Møller, Erik Hvid Danielsen, Morten Blaabjerg, Matthias Bode, Tomasz Brudek, Susana Aznar   +15 more
wiley   +1 more source

Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Concurrent Alzheimer's disease pathology is increasingly recognized as a poor prognostic factor in Parkinson's disease (PD), yet reliable clinical indicators for early identification of AD copathology remain poorly established.
Han Kyu Na, Yeeun Sun, Chan Wook Park, Jung Hyun Lee, Yun Young Choi, Quynh Phuong Vo, Seok Jong Chung, Han Soo Yoo, Chul Hyoung Lyoo, Young H. Sohn, Jin Yong Hong, Phil Hyu Lee   +11 more
wiley   +1 more source

Analysis of quality of life of elderly patients with orthostatic hypotension in Nantong community and its influencing factors

Huli yanjiu, 2017
Objective:To probe into the quality of life of elderly patients with orthostatic hypotension in a community in Nantong and its influencing factors. Methods:A total of 185 cases of elderly patients with orthostatic hypotension were investigated by using ...
钱湘云, 耿桂灵, 谢幸尔, 黄春雨, 陈春梅, 黄金燕   +5 more
doaj  

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, EarlyView.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

Atherosclerosis of the carotid bulb is associated with the severity of orthostatic hypotension in non-diabetic adult patients: a cross-sectional study

Clinical and Experimental Hypertension, 2019
Background: The carotid bulb has a high density of baroreceptors that play an important role in maintaining blood pressure. We hypothesized that atherosclerosis of the carotid bulb would reflect the severity of orthostatic hypotension more accurately ...
Yusuke Kobayashi, Hiroaki Ishiguro, Tetsuya Fujikawa, Hideo Kobayashi, Koichiro Sumida, Minako Kagimoto, Yuki Okuyama, Yosuke Ehara, Mari Katsumata, Megumi Fujita, Akira Fujiwara, Sanae Saka, Keisuke Yatsu, Nobuhito Hirawa, Yoshiyuki Toya, Gen Yasuda, Satoshi Umemura, Kouichi Tamura   +17 more
doaj   +1 more source

No increased risk of spinal cerebrospinal fluid leak after spinal manipulative therapy: A retrospective cohort study

PM&R, EarlyView.
Abstract Background Spinal cerebrospinal fluid (CSF) leaks, a rare but debilitating condition, have been described following spinal manipulative therapy (SMT) in case reports. However, the nature of the potential association between SMT and CSF leak is uncertain, and symptoms such as neck pain or headache may reflect preexisting leaks rather than ...
Robert J. Trager, Collin M. Labak, Anthony N. Baumann, Tyler H. Snodgrass, Zachary A. Cupler   +4 more
wiley   +1 more source