Results 41 to 50 of about 8,495 (166)

Review of published research on primary dysautonomia of domestic animals

Veterinary Record, EarlyView.
Abstract An article published in 1992 by Marion M. Pollin and I.R. Griffiths reviewed the topic of primary dysautonomias of the autonomic nervous system of unidentified origin in multiple domestic species, specifically cats, dogs and horses. Thirty‐one years later, we appear no closer to identifying the causal agents of these strikingly similar ...
Tanith Harte, David Smith, Jo Moore, Beth Wells   +3 more
wiley   +1 more source

External validation of a simple clinical tool used to predict falls in people with Parkinson disease [PDF]

, 2015
Published in final edited form as: Parkinsonism Relat Disord. 2015 August ; 21(8): 960–963. doi:10.1016/j.parkreldis.2015.05.008.BACKGROUND: Assessment of fall risk in an individual with Parkinson disease (PD) is a critical yet often time consuming ...
Canning, Colleen G., Cavanaugh, James T., Dibble, Leland E., Duncan, Ryan P., Earhart, Gammon M., Ellis, Terry D., Ford, Matthew P., Foreman, K. Bo, Leddy, Abigail L., Paul, Serene S., Thackeray, Anne   +10 more
core   +1 more source

Pharmacokinetics and safety of eptinezumab in children and adolescents with migraine

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The primary objective was to characterize the pharmacokinetics (PK) and safety of eptinezumab in children and adolescents with migraine. Background Migraine in children and adolescents is a prevalent and potentially debilitating disease, and few preventive therapies are approved for use in these populations. Eptinezumab, a calcitonin
Andrew D. Hershey, Johan Areberg, Line Pickering Boserup, Annika Lindsten, Monika Rosen   +4 more
wiley   +1 more source

The emergency department evaluation and outcomes of elderly fallers [PDF]

, 2016
BACKGROUND: Approximately one-third of community dwelling elderly people (age ≥65 years) falls each year contributing to over 2 million elderly emergency department (ED) visits for falls annually.
Tirrell, Gregory
core   +1 more source

Neuroimmune pathophysiology of long COVID

Psychiatry and Clinical Neurosciences, EarlyView.
Although COVID‐19 was originally considered a respiratory illness, it is now well established that SARS‐CoV‐2 infection can have far‐reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID‐19 cases will go on to develop new or persistent
Janna K. Moen, Christopher A. Baker, Akiko Iwasaki   +2 more
wiley   +1 more source

An eye on long‐duration spaceflight: Controversies, countermeasures and challenges

Experimental Physiology, EarlyView.
Abstract Space flight‐associated neuroocular syndrome (SANS) is a consequence of long‐duration space flight and is detected in two‐thirds of astronauts. In‐flight, this can cause a change in the refraction of the eyes, requiring graded hypermetropic ‘superfocus adjustable’ glasses, optic nerve head oedema and choroidal folds.
Vincent Wing Sum Ng, Susan Patricia Mollan   +1 more
wiley   +1 more source

Submaximal 2‐day cardiopulmonary exercise testing to assess exercise capacity and post‐exertional symptom exacerbation in people with long COVID

Experimental Physiology, EarlyView.
Abstract Long COVID has a complex pathology and a heterogeneous symptom profile that impacts quality of life and functional status. Post‐exertional symptom exacerbation (PESE) affects one‐third of people living with long COVID, but the physiological basis of impaired physical function remains poorly understood. Sixty‐eight people (age (mean ± SD): 50 ± 
Callum Thomas, Nik Kudiersky, Paul Ansdell, Ruth E Ashton, Calum Brown, Thomas Bewick, Jack Carr, Emily Hume, Padraig Spillane, Elisa Pastorio, Rebecca Owen, Tom Maden‐Wilkinson, Ethan McNeil‐Angopa, Tom Parkington, Ross Arena, Cemal Ozemek, Federico Formenti, Sundar Kumar Veluswamy, Rachita Gururaj, Mark A. Faghy   +19 more
wiley   +1 more source

Weight Loss and Illness Severity in Adolescents With Atypical Anorexia Nervosa. [PDF]

, 2019
BACKGROUND:Lower weight has historically been equated with more severe illness in anorexia nervosa (AN). Reliance on admission weight to guide clinical concern is challenged by the rise in patients with atypical anorexia nervosa (AAN) requiring ...
Accurso, Erin C, Adams, Sally H, Buckelew, Sara M, Cheng, Jing, Garber, Andrea K, Golden, Neville H, Kapphahn, Cynthia J, Kreiter, Anna, Le Grange, Daniel, Machen, Vanessa I, Moscicki, Anna-Barbara, Saffran, Kristina, Sy, Allyson F, Wilson, Leslie   +13 more
core  

Fall Prediction and Prevention Systems: Recent Trends, Challenges, and Future Research Directions. [PDF]

, 2017
Fall prediction is a multifaceted problem that involves complex interactions between physiological, behavioral, and environmental factors. Existing fall detection and prediction systems mainly focus on physiological factors such as gait, vision, and ...
Jung, Tzyy-Ping, Litvan, Irene, Rajagopalan, Ramesh   +2 more
core   +2 more sources

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 164-176, July 2025.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source