Results 41 to 50 of about 9,253 (193)

Orthostatic blood pressure reactions and resting heart rate in relation to lung function - the Swedish CArdioPulmonary bioImage Study (SCAPIS)

BMC Pulmonary Medicine
Background There is a well-known comorbidity between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) which is only partially explained by common risk factors.
Andreas Casselbrant, Christian Zambach, Artur Fedorowski, Gunnar Engström, Per Wollmer, Viktor Hamrefors   +5 more
doaj   +1 more source

Disease modifying therapy for multiple system atrophy – Parkinsonian Type [PDF]

, 2017
BACKGROUND: Multiple System Atrophy –Parkinsonian Type (MSA-P) is a rare, rapidly progressive neurodegenerative disease without any current treatment.
Dwyer, Sean Sullivan
core  

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

The emergency department evaluation and outcomes of elderly fallers [PDF]

, 2016
BACKGROUND: Approximately one-third of community dwelling elderly people (age ≥65 years) falls each year contributing to over 2 million elderly emergency department (ED) visits for falls annually.
Tirrell, Gregory
core   +1 more source

Post-Partum Pituitary Insufficiency and Livedo Reticularis Presenting a Diagnostic Challenge in a Resource Limited Setting in Tanzania: A Case Report, Clinical Discussion and Brief Review of Existing Literature. [PDF]

, 2012
Pituitary disorders following pregnancy are an important yet under reported clinical entity in the developing world. Conversely, post partum panhypopituitarism has a more devastating impact on women in such settings due to high fertility rates, poor ...
A Cénac, A Gutenberg, A Lecube, AH Zargar, C Ajith, D Castle, EH Sidibe, EM Tan, F Bakiri, Faheem G Sheriff, GK Leung, H Raff, HC Lee, J Honegger, JD Ji, JR Ouma, Kajiru G Kilonzo, ME Molitch, N Tubridy, P Caturegli, R Golden, R Goswami, RA Kristof, S Diederich, William P Howlett, Y Ozawa, Z Karaca, ZA Erkut   +27 more
core   +3 more sources

Global patterns of polypharmacy after acute heart failure hospitalization: Prevalence and outcomes from the REPORT‐HF registry

European Journal of Heart Failure, EarlyView.
Global patterns of polypharmacy after acute heart failure hospitalization. GDMT, guideline‐directed medical therapy; HF, heart failure. Aims Polypharmacy, defined as the concurrent use of ≥5 medications, is prevalent among older adults with heart failure (HF).
Wan Ting Tay, Tiew‐Hwa Katherine Teng, Wouter Ouwerkerk, John G.F. Cleland, Sean P. Collins, Christiane E. Angermann, Kenneth Dickstein, Ulf Dahlstrom, Anja Schweizer, Achim Obergfell, Kai‐Hang Yiu, Mathieu Ghadanfar, Mahmoud Hassanein, Qing‐Wen Ren, Wen‐Li Gu, Georg Ertl, Sergio V. Perrone, Gerasimos Filippatos, Carolyn S.P. Lam, Jasper Tromp   +19 more
wiley   +1 more source

Combined Effects of Depression, Fatigue and Cardiovascular Dysfunction on Functional Dependence Over Seven Years in Early Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is associated with both motor and non‐motor symptoms, which collectively impact activities of daily living (ADLs) and contribute to the loss of functional independence. There is a lack of understanding of how non‐motor symptoms drive this loss in independence.
Charlotte B. Stewart, Sahana Sathyanarayana, Victoria K. Foster, Robyn Iredale, Debra Galley, Jacopo Pasquini, Kirstie N. Anderson, Nicola Pavese, David Ledingham   +8 more
wiley   +1 more source

Review of published research on primary dysautonomia of domestic animals

Veterinary Record, EarlyView.
Abstract An article published in 1992 by Marion M. Pollin and I.R. Griffiths reviewed the topic of primary dysautonomias of the autonomic nervous system of unidentified origin in multiple domestic species, specifically cats, dogs and horses. Thirty‐one years later, we appear no closer to identifying the causal agents of these strikingly similar ...
Tanith Harte, David Smith, Jo Moore, Beth Wells   +3 more
wiley   +1 more source

Rapid Intervention to Support Eating Issues (RISE) Program: Using Quality Improvement to Reduce Medical Hospitalization in Malnourished Youth

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Program‐led and focused models may overcome structural barriers to accessing ED care, such as limited availability, for youth with EDs by prioritizing strategic, evidence‐based care delivered through a structured approach. The Rapid Intervention to Support Eating Issues (RISE) pilot aimed to promote weight restoration and prevent ...
Michele Calderoni, Samantha Turner, Kerri Heckert, Carrie Snyder, Nicole Cifra, Rebecka Peebles, Karen Foy, Jonathan Walsh, Amanda O. Widders, C. Alix Timko   +9 more
wiley   +1 more source