Results 41 to 50 of about 76,723 (183)

Neuroimmune pathophysiology of long COVID

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Although COVID‐19 was originally considered a respiratory illness, it is now well established that SARS‐CoV‐2 infection can have far‐reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID‐19 cases will go on to develop new or persistent
Janna K. Moen   +2 more
wiley   +1 more source

An eye on long‐duration spaceflight: Controversies, countermeasures and challenges

open access: yesExperimental Physiology, EarlyView.
Abstract Space flight‐associated neuroocular syndrome (SANS) is a consequence of long‐duration space flight and is detected in two‐thirds of astronauts. In‐flight, this can cause a change in the refraction of the eyes, requiring graded hypermetropic ‘superfocus adjustable’ glasses, optic nerve head oedema and choroidal folds.
Vincent Wing Sum Ng   +1 more
wiley   +1 more source

Submaximal 2‐day cardiopulmonary exercise testing to assess exercise capacity and post‐exertional symptom exacerbation in people with long COVID

open access: yesExperimental Physiology, EarlyView.
Abstract Long COVID has a complex pathology and a heterogeneous symptom profile that impacts quality of life and functional status. Post‐exertional symptom exacerbation (PESE) affects one‐third of people living with long COVID, but the physiological basis of impaired physical function remains poorly understood. Sixty‐eight people (age (mean ± SD): 50 ± 
Callum Thomas   +19 more
wiley   +1 more source

Efficacy and Safety of Once Daily Dosing vs. Approved On/Off Dosing of Edaravone Oral Suspension Up to 48 Weeks in Patients With Amyotrophic Lateral Sclerosis (Study MT‐1186‐A02)

open access: yesMuscle &Nerve, Volume 72, Issue 3, Page 433-442, September 2025.
ABSTRACT Introduction/Aims An On/Off dosing regimen of intravenous (IV) edaravone and edaravone oral suspension is approved in the US for the treatment of amyotrophic lateral sclerosis (ALS). Placebo‐controlled clinical trials showed IV edaravone slows the rate of physical functional decline.
Jeffrey Rothstein   +17 more
wiley   +1 more source

Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies

open access: yesAlzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract Dementia with Lewy bodies (DLB), a progressive neurodegenerative disease with heterogeneous clinical presentations, greatly impacts patients, caregivers, and society. Despite its frequency, diagnosing and treating DLB remains challenging. Advances in in vivo biomarker assays reflecting underlying pathology are improving disease identification,
Jennifer G. Goldman   +19 more
wiley   +1 more source

Vaccines in Current Culture: The HPV Vaccine Controversy [PDF]

open access: yes, 2020
The use of vaccinations has drastically decreased mortality and morbidity rates related to infectious disease and has become an intrinsic part of modern health care.
Johnston, Alyssa
core   +1 more source

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 164-176, July 2025.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr   +12 more
wiley   +1 more source

Analysis of the Current Status and Influencing Factors of Social Alienation in Adolescent Scoliosis Patients

open access: yesOrthopaedic Surgery, Volume 17, Issue 7, Page 2121-2129, July 2025.
Multivariate linear regression analysis reveals significant social isolation in adolescent scoliosis patients, influenced by education level, family income, disease onset time, scoliosis type, Cobb's angle, self‐care ability, appearance deformation, family care, and anxiety levels.
Yi Zeng, Qin Fu, Xia Li
wiley   +1 more source

Weight Loss and Illness Severity in Adolescents With Atypical Anorexia Nervosa. [PDF]

open access: yes, 2019
BACKGROUND:Lower weight has historically been equated with more severe illness in anorexia nervosa (AN). Reliance on admission weight to guide clinical concern is challenged by the rise in patients with atypical anorexia nervosa (AAN) requiring ...
Accurso, Erin C   +13 more
core  

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