Results 41 to 50 of about 1,698,662 (287)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
On estimates for norms of matrix operators: the case q
Қарағанды университетінің хабаршысы. Математика сериясыThe study of matrix operators acting between weighted sequence spaces lp,v and lq,u has become an important direction in functional analysis, particularly due to its close connection with Hardy-type inequalities and the general theory of linear ...
K.D. Kuliev +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
matrix-toolbox/CHM_scripts: Sinkhorn Algorithm
, 2023 Several CHM matrices (M-scripts) obtained by the Sinkhorn Algorithm are ...
matrix-toolbox
core +1 more source
STAR ProtocolsSummary: Here, we present a numerical framework to quantify the energy landscape of high-dimensional stochastic oscillatory systems, based on the diffusion decomposition of Gaussian approximation (DDGA).
Shirui Bian +3 more
doaj +1 more source
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
GMRES for oscillatory matrix-valued differential equations [PDF]
, 2009 We investigate the use of Krylov subspace methods to solve linear, oscillatory ODEs. When we apply a Krylov subspace method to a properly formulated equation, we retain the asymptotic accuracy of the asymptotic expansion whilst converging to the exact ...
Sheehan Olver, Olver, Sheehan
core
Generalized reciprocity principle for discrete symplectic systems
Electronic Journal of Qualitative Theory of Differential Equations, 2015 This paper studies transformations for conjoined bases of symplectic difference systems $Y_{i+1}=\mathcal S_{i}Y_{i}$ with the symplectic coefficient matrices $\mathcal S_i.$ For an arbitrary symplectic transformation matrix $P_{i}$ we formulate most ...
Julia Elyseeva
doaj +1 more source
Krylov SSP Integrating Factor Runge–Kutta WENO Methods
Mathematics, 2021 Weighted essentially non-oscillatory (WENO) methods are especially efficient for numerically solving nonlinear hyperbolic equations. In order to achieve strong stability and large time-steps, strong stability preserving (SSP) integrating factor (IF ...
Shanqin Chen
doaj +1 more source
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source