Results 41 to 50 of about 26,698 (263)
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Qualitative Behavior of the Solutions to Delay and Difference Equations
It is noteworthy to observe that a first-order linear ordinary differential equation without delay does not possess oscillatory solutions. Therefore the investigation of oscillatory solutions is of interest for equations with delays or for the discrete
P. Ioannis
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Oscillatory behavior of solutions of Volterra summation equations
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Graef, J.R., Thandapani, E.
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Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
In this paper, the distributions of generalized zeros of oscillatory solutions for second-order nonlinear neutral delay difference equations are studied.
Limei Feng, Zhenlai Han
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Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Qualitative properties of solutions of certain fourth order linear differential equations
This work considers differential equations of the form (py″)′′+qy″+ry=0 where p,q and r are positive continuous functions defined on [0,∞). The main concentration is on the oscillatory and asymptotic behavior of the solutions.
W. E. Taylor
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Stationary and oscillatory dynamics of Nicholson's blowflies equation with Allee effect
In this article we analyze the bistable dynamics of a Nicholson's blowflies equation with Allee effect. Using Lyapunov-LaSalle invariance principle, we study the stability and basins of attraction of multiple equilibria.
Cuiping Guo, Shangjiang Guo
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Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias +3 more
wiley +1 more source
Oscillation of third-order neutral damped differential equations
We study a third-order damped neutral sublinear differential equation whose differential operator is non-oscillatory. Specifically, we obtain sufficient conditions for all solutions to be oscillatory.
Miroslav Bartusek
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