Results 41 to 50 of about 26,698 (263)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Qualitative Behavior of the Solutions to Delay and Difference Equations

open access: yesВестник КазНУ. Серия математика, механика, информатика, 2018
It is noteworthy to observe that a first-order linear ordinary differential equation without delay does not possess oscillatory solutions. Therefore the investigation of oscillatory solutions is of interest for equations with delays or for the discrete
P. Ioannis
doaj   +1 more source

Oscillatory behavior of solutions of Volterra summation equations

open access: yesApplied Mathematics Letters, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Graef, J.R., Thandapani, E.
openaire   +2 more sources

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin   +8 more
wiley   +1 more source

The distribution of generalized zeros of oscillatory solutions for second-order nonlinear neutral delay difference equations

open access: yesAdvances in Difference Equations, 2019
In this paper, the distributions of generalized zeros of oscillatory solutions for second-order nonlinear neutral delay difference equations are studied.
Limei Feng, Zhenlai Han
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

Qualitative properties of solutions of certain fourth order linear differential equations

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1981
This work considers differential equations of the form (py″)′​′+qy″+ry=0 where p,q and r are positive continuous functions defined on [0,∞). The main concentration is on the oscillatory and asymptotic behavior of the solutions.
W. E. Taylor
doaj   +1 more source

Stationary and oscillatory dynamics of Nicholson's blowflies equation with Allee effect

open access: yesElectronic Journal of Differential Equations, 2022
In this article we analyze the bistable dynamics of a Nicholson's blowflies equation with Allee effect. Using Lyapunov-LaSalle invariance principle, we study the stability and basins of attraction of multiple equilibria.
Cuiping Guo, Shangjiang Guo
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

Oscillation of third-order neutral damped differential equations

open access: yesElectronic Journal of Differential Equations, 2021
We study a third-order damped neutral sublinear differential equation whose differential operator is non-oscillatory. Specifically, we obtain sufficient conditions for all solutions to be oscillatory.
Miroslav Bartusek
doaj   +1 more source

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