Results 111 to 120 of about 84,971 (337)

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

meso-Tetrahexyl-7,8-dihydroxychlorin and Its Conversion to ß-Modified Derivatives

Molecules
meso-Tetrahexylporphyrin was converted to its corresponding 7,8-dihydroxychlorin using an osmium tetroxide-mediated dihydroxylation strategy. Its diol moiety was shown to be able to undergo a number of subsequent oxidation reactions to form a chlorin ...
Daniel Aicher, Dinusha Damunupola, Christian B. W. Stark, Arno Wiehe, Christian Brückner   +4 more
doaj   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Rapid in-EPON CLEM: Combining fast and efficient labeling of self-labeling enzyme tags with EM-resistant Janelia Fluor dyes and StayGold

Heliyon
Correlative light and electron microscopy (CLEM) combines light microscopy (LM) of fluorescent samples to ultrastructural analyses by electron microscopy (EM).
Rico Franzkoch, Sabrina Wilkening, Viktoria Liss, Michael Holtmannspötter, Rainer Kurre, Olympia E. Psathaki, Michael Hensel   +6 more
doaj   +1 more source

Stepwise Regulation of Cellular Oxidative Stress via Conductive‐Piezoelectric Integrated Microstructured Conduits for Enhanced Nerve Regeneration

Advanced Science, EarlyView.
This study presents a conductive‐piezoelectric integrated microstructured conduit for peripheral nerve regeneration. The conduit combines reduced graphene oxide with a piezoelectric nanofiber membrane, enhancing nerve repair through physical guidance, oxidative stress inhibition, and ultrasound‐activated electrical stimulation.
Dong Zhou, Mengxuan Bian, Lingyu Wei, Binghuang Yao, Qi Chen, Lan Xiao, Jing He, Jian Zhang, Yulin Li, Libo Jiang   +9 more
wiley   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source

HISTOLOGY AND HISTOPATHOLOGY OF BLOOD VESSELS: BACKSCATTERED SCANNING ELECTRON MICROSCOPY APPROACH

Фундаментальная и клиническая медицина, 2019
Aim. To study the technical possibility of em-ploying the original technique of long-term osmium tetroxide postfixation and uranyl acetate/lead citrate counterstaining with the following embedding into epoxy resin for the investigation of histological ...
RINAT A. Mukhamadiyarov, ANTON G. Kutikhin   +1 more
doaj  

ELEMENTAL ANALYSIS OF PRECIPITATES FORMED IN NUCLEI BY ANTIMONATE-OSMIUM TETROXIDE FIXATION [PDF]

, 1972
S. S. Spicer, A. A. SWANSON
openalex   +1 more source

Multifunctional Gelatin‐Based Smart Films Integrating Thermochromic Encryption, Temperature‐Regulated Photothermal Management, Reprocessability, and Biodegradability for Sustainable Applications

Advanced Science, EarlyView.
Multifunctional gelatin films synergizing thermochromic encryption, self‐regulating photothermal management, and closed‐loop recyclability offer sustainable solutions for intelligent packaging. ABSTRACT Multifunctional gelatin‐based smart films are engineered by incorporating hyperbranched polyglycerol (HBPG) as a plasticizer, dialdehyde β‐cyclodextrin
Yuehong Zhang, Chen Yang, Langlang Dai, Leipeng Liu, Vijay Kumar Thakur   +4 more
wiley   +1 more source

In situ Generation of Ruthenium Tetroxide and Osmium Tetroxide for the Physical Sciences and Their Reaction Indicators [PDF]

, 2002
Paul Victor Beauregard
openalex   +1 more source