Results 241 to 250 of about 84,971 (337)

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen   +18 more
wiley   +1 more source

Three-Dimensional Visualization of the Cardiac Stroma. [PDF]

open access: yesCells
Kleefeldt F   +4 more
europepmc   +1 more source

Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK‐ULK1‐Mediated Mitochondrial Quality Control

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Dietary protein restriction protects the aging heart in the context of obesity by limiting mitochondrial DNA leakage and suppressing cGAS–STING‐driven inflammation. Through AMPK–ULK1‐dependent mitophagy, protein restriction restores mitochondrial quality control, reduces cardiac remodeling, and preserves metabolic homeostasis during obesity‐associated ...
Wagner S. Dantas   +8 more
wiley   +1 more source

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Wayne Mitchell   +9 more
wiley   +1 more source

Human Skeletal Muscle Mitochondria Responses to Weight Loss Induced by Bariatric Surgery or Lifestyle Intervention

open access: yesActa Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim We investigated how weight loss induced by bariatric surgery or lifestyle intervention affects skeletal muscle mitochondrial metabolism. Methods We studied two weight‐loss cohorts: RYSA (BMI ≥ 35 kg/m2; n = 39, including 18 with diabetes) undergoing bariatric surgery, and CRYO (BMI ≥ 30 kg/m2; n = 19) undergoing a lifestyle intervention ...
Birgitta W. van der Kolk   +16 more
wiley   +1 more source

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