Results 81 to 90 of about 84,971 (337)
Advanced Science, EarlyView.CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan +10 more
wiley +1 more source
Advanced Science, EarlyView.In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou +10 more
wiley +1 more source
Ruthenium Tetroxide: A Complementary Fixative and Stain to Osmium Tetroxide [PDF]
Microscopy Today, 1999 Abstract Ruthenium tetroxide (RuO4), which is a stronger oxidizing agent than osmium tetroxide (OSO4), reacts well with some of the more polar lipids that fail to show a reaction with OsO4 . it has been demonstrated that the use of RuO4 can overcome the failure of OsC4 to visualize epidermal intercellular lamellae.
openaire +1 more source
Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants
Advanced Science, EarlyView.In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao +12 more
wiley +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Advanced Science, EarlyView.PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao +6 more
wiley +1 more source
Notes on improved procedures for the chemical modification and degradation of glycosphingolipids.
Journal of Lipid Research, 1980 Some simplified and efficient procedures are described for the following chemical modifications of glycophingolipids. 1) The olefinic bond of the ceramide moiety of the acetylated glycolipid was quantitatively oxidized with osmium tetroxide and periodic ...
D L MacDonald, L M Patt, S Hakomori
doaj +1 more source
Potassium permanganate is an excellent alternative to osmium tetroxide in freeze-substitution. [PDF]
Histochem Cell Biol, 2022 Schauflinger M +4 more
europepmc +1 more source
NUCLEAR PRECIPITATES IN PYROANTIMONATE-OSMIUM TETROXIDE-FIXED TISSUES
Journal of Cell Biology, 1968 Recent biochemical studies indicate a significant role for sodium ions in nuclear metabolism. Protein and nucleic acid syntheses in the nucleus depend upon sodium, apparently through a stimulating effect of this cation on the transport of amino acid ...
S. Spicer, J. H. Hardin, W. Greene
semanticscholar +1 more source
Advanced Science, EarlyView.EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo +18 more
wiley +1 more source