Results 41 to 50 of about 6,598,473 (249)

P62 DAPAGLIFLOZIN PRESERVES RENAL VASODILATING CAPACITY IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES

Artery Research, 2018
Aim: Mechanisms through which SGLT-2 inhibitors achieve cardiovascular and renal protection are still unknown. We investigated whether dapagliflozin modulates Na and water balance and systemic and renal vascular parameters like endothelial function ...
Rosa Maria Bruno, Livia Giannini, Angela Dardano, Edoardo Biancalana, Stefano Taddei, Lorenzo Ghiadoni, Anna Solini   +6 more
doaj   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Fisiopatología celular de la osteoartritis: el condrocito articular como protagonista = Osteoarthritis cellular pathophysiology: The articular chondrocyte as a central player

Iatreia, 2011
La osteoartritis es una de las enfermedades más prevalentes y que más discapacidad produce en todo el mundo, lo que ocasiona costos altos para el paciente y la sociedad.
Sánchez Naranjo, Julio César, López Zapata, Diego Fernando   +1 more
doaj  

Tracheal epithelium cell volume responses to hyperosmolar, isosmolar and hypoosmolar solutions: relation to epithelium-derived relaxing factor (EpDRF) effects

Frontiers in Physiology, 2013
In asthmatic patients, inhalation of hyperosmolar saline or D-mannitol (D-M) elicits bronchoconstriction, but in healthy subjects exercise causes bronchodilation. Hyperventilation causes drying of airway surface liquid (ASL) and increases its osmolarity.
Jeffrey S. Fedan, Janet A. Thompson, U. Burcin Ismailoglu, Yi eJing   +3 more
doaj   +1 more source

Relationship between extracellular osmolarity, NaCl concentration and cell volume in rat glioma cells

General Physiology and Biophysics, 2011
The cell volume, which controls numerous cellular functions, is theoretically linearly related with the inverse osmolarity. However, deviations from this law have often been observed. In order to clarify the origin of these deviations we electronically measured the mean cell volume of rat glioma cells under three different experimental conditions ...
Rouzaire-Dubois, Béatrice, Ouanounou, Gilles, Dubois, Jean Marc   +2 more
openaire   +4 more sources

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome

Revista Brasileira de Oftalmologia
Purpose: Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by chronic anovulation and hyperandrogenism. Hormonal changes can affect tear function.
Derya Alp Guliyev, Kubra Serefoglu Cabuk, Ahmet Kirgiz, Abdullah Taner Usta, Evrim Ebru Kovalak, Vusal Guliyev, Muhittin Taskapili   +6 more
doaj   +1 more source

Selective Osmotic Shock for Islet Isolation in the Cadaveric Canine Pancreas

Cell Transplantation, 2018
Currently, islet isolation is performed using harsh collagenases that cause nonspecific injury to both islets and exocrine tissue, negatively affecting the outcome of cell transplantation.
Elizabeth M. Thompson, Jennifer L. Sollinger, Emmanuel C. Opara, Christopher A. Adin   +3 more
doaj   +1 more source

Sucrose Concentration and Osmolarity as Factors Affecting in Vitro Wax Accumulation in Jojoba Embryos

HortScience, 1986
Abstract Immature zygotic embryos of jojoba ( Simmondsia chinensis Link) (average 5.6 mm in length about 2 months after pollination) were cultured on semisolid or in liquid basal medium for 8 weeks.
Yi-Chang Wang, Jules Janick
openaire   +1 more source