Results 61 to 70 of about 2,479,763 (143)

Osmolar gap in hyponatraemia—an exploratory study [PDF]

Hyponatraemia has indeed been extensively studied from multiple angles, including volume status, tonicity, and aetiology; however, the specific consideration of the osmolar gap (OG) within the context of hyponatraemia and its potential impact on their ...
Shoukat Memon, Ashar Alam, Javeria Chughtai, Salman Imtiaz, Faiza Saeed   +4 more
core   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Sustancias de contraste para estudios radiográficos en cardiología intervencionista

Revista Cubana de Medicina, 2002
Las sustancias de contraste (SC) radiográficas utilizadas en Cardiología se clasifican en: 1. Iónicas de osmolalidad muy alta (OMA); 2. No iónicas de osmolalidad no muy alta (ONMA); 3. Iónicas de ONMA; 4. No iónicas Isosmolares.
Luis Roberto Llerena Rojas, Lorenzo D. Llerena Rojas   +1 more
doaj  

Ferulic Acid Modulates High Glucose-Induced MMP-1/TIMP-1 Imbalance and Enhances Wound Closure of Human Gingival Fibroblasts

Biomedicines
Background/Objectives: Chronic hyperglycemia drives gingival fibroblast dysfunction, disrupting extracellular matrix homeostasis and the migratory capacity required for wound healing, which contributes to increased periodontal susceptibility in diabetes.
Akın Özdemir, Ali Yüncü, Ayşe Mine Yılmaz, Hafize Öztürk Özener   +3 more
doaj   +1 more source

Under‐Explored Species, Breeds and Cell Types With Potential for Cultivated Meat Production

Food Bioengineering, EarlyView.
This graphical abstract illustrates how the strategic selection of overlooked cell lines from novel species and specific agricultural breeds can help overcome current manufacturing bottlenecks in cultivated meat production. The schematic links the concept of an ‘ideal cell line’ to four key bioprocessing and product advantages that can be optimised ...
William Gordon‐Petrovskii, Maanasa Ravikumar, Travis Callue, Maria Laura Vieri, Michael Sulu, Gary J. Lye, Mariana Petronela Hanga   +6 more
wiley   +1 more source

Unmasking of a Heterozygous SLC12A3 Variant

Kidney Medicine
Three months after starting 25 mg chlorthalidone, a patient was admitted to the medical intensive care unit to manage hypokalemia, metabolic alkalosis, hypo-osmolar hyponatremia, hyperglycemia, and 30 lb weight loss.
Chang Xu, Pietra Greenberg, Moses Bachan, Rajeev Rohatgi   +3 more
doaj   +1 more source

concentration

, 2022
the concentration of 51 aluminium alloy ...
ge xie (13814806)
core   +1 more source

Physical stability of RNA–lipid nanoparticles under agitation, freeze–thaw and accelerated stability testing

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras, Leah Wright, Robert J Falconer   +2 more
wiley   +1 more source

Comparative evaluation of gold nanoparticles as contrast agent in multimodality diagnostic imaging

Journal of Radiation Research and Applied Sciences
A contrast agent is clinically employed to aid the visualization of organs and structures when imaged by radiation based diagnostic imaging modalities.
Noor Nabilah Talik Sisin, Raizulnasuha Ab Rashid, Ahmad Zaky Harun, Moshi Geso, Wan Nordiana Rahman   +4 more
doaj   +1 more source

Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley   +1 more source