Results 51 to 60 of about 4,749 (223)

Effect of Linaclotide on Colonic Motility Assessed With Intraluminal Colonic High‐Resolution Manometry in Healthy Subjects. An Acute, Open Label, Randomized, Crossover, Reader‐Blinded Study

Neurogastroenterology &Motility, EarlyView.
Our study showed that, in healthy controls, acute administration of linaclotide increased the total number of long‐distance propagating and the pre‐prandial pancolonic pressurizations. Further studies need to address whether the observed effects are directly or indirectly mediated by the mechanism of action of this useful medication to treat chronic ...
Christian Lambiase, Giuseppe Pagliaro, Silvia Cocca, Eveline Deloose, Ingrid Demedts, Riccardo Morganti, Jan Tack, Maura Corsetti   +7 more
wiley   +1 more source

Paediatrics: how to manage functional constipation

Drugs in Context, 2021
Background: Despite being a common problem in childhood, functional constipation is often difficult to manage. This article provides a narrative updated review on the evaluation, diagnosis and management of childhood functional constipation.
Alexander KC Leung, Kam Lun Hon
doaj   +1 more source

Opioid-Induced constipation: Pathophysiology, Treatment and Management [PDF]

, 2016
Opioid analgesics are increasingly used to alleviate severe acute and chronic pain. Opioid Induced Constipation (OIC) is the most common side effect of opioid analgesia which can have a significant effect on the persons’ quality of life and lead some to ...
Bajwa A, Blane R, Emmanuel A, Fallon M, Jeong ID, Joint Formulary Committee, Muller-Lissner S   +6 more
core   +1 more source

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö, Émeline Courtois, Anne Paakinaho, Sirpa Hartikainen, Valtteri Kaasinen, Alexis Elbaz, Anne C. M. Thiébaut, Ismaïl Ahmed, Anna‐Maija Tolppanen   +8 more
wiley   +1 more source

Functional constipation in young children: causes, diagnostic criteria and therapeutic strategies

Медицинский совет, 2018
The article gives a modern definition of constipation and working classification used in Pediatrics; frequency of defecation and qualitative characteristics of stool depending on age and type of feeding are presented.
N. M. Bogdanova
doaj   +1 more source

Modern and promising ways of bowel preparation for instrumental research

Амбулаторная хирургия, 2021
A review is presented to summarize data on intestinal preparation approaches and methods for research. The historical background and main stages in the development of the intestinal lavage method are highlighted, and traditional and modern methods of ...
E. V. Kanner, M. L. Maximov, A. S. Ermolaeva, I. D. Kanner, N. M. Lapkin   +4 more
doaj   +1 more source

Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes

Journal of Diabetes Investigation, Volume 17, Issue 3, Page 420-431, March 2026.
In individuals with type 1 diabetes, immune cell infiltration in the colon mucosa tended to correlate with fecal and systemic markers of intestinal permeability and inflammation, as well as gastrointestinal symptoms. These findings suggest that low‐grade gut immune activation might link the intestinal barrier dysfunction with systemic endotoxin ...
Polina Zalizko, Reinis Isaks, Leonora Pahirko, Aleksejs Fedulovs, Eduards Krustins, Jurijs Nazarovs, Sergejs Dubencovs, Hanne Salmenkari, Markku Lehto, Kaspars Jēkabsons, Una Riekstiņa, Per‐Henrik Groop, Niina Sandholm, Jeļizaveta Sokolovska   +13 more
wiley   +1 more source

Fecal Retention in Overactive Bladder (OAB) in Children: Perspective of a Pediatric Gastroenterologist [PDF]

Childhood Kidney Diseases, 2015
Coexisting voiding and bowel dysfunction in children are common in the clinic. The idea that overactive bladder (OAB) and constipation arise from one single pathophysiology has been reinforced in many studies.
Su Jin Jeong
doaj   +1 more source

Incidence and predictors of new-onset constipation during acute hospitalisation after stroke [PDF]

, 2015
Objectives: We investigated new-onset constipation in patients with stroke compared with orthopaedic conditions and explored the predictors associated with constipation during acute hospitalisation. Methods: This was a prospective matched cohort study of
Bell, Bove, Bracci, Cameron, Cardin, Davenport, Dennison, Doshi, Dukas, Fleming, Gattinger, Harari, Ingeman, Ishihara, Ishihara, Klaschik, Kortte, Langhorne, Lim, Masri, Ng, Otegbayo, Pashikanti, Rao, Rao, Robain, Saxer, Schryver, Sendir, Su, Tack, Ullman, Winge   +32 more
core   +1 more source

Preliminary non‐comparative evaluation of an adapted colonoscopy preparation protocol for dogs using sodium picosulphate and magnesium citrate

Veterinary Record, Volume 198, Issue 3, Page e101-e107, 31 January/7 February 2026.
Abstract Background Challenges associated with bowel cleansing protocols for canine colonoscopy include practical applicability and inadequate preparations. This study aimed to describe and evaluate an adapted protocol to simplify colonoscopy preparation in dogs.
Julia Elia da Silva Paranhos, Melissa Guillen Gonçalves de Souza, Daniela Araujo de Sousa, Debora Costabile Soibelman, Sabrina Martins da Costa Ferreira, Juliana da Silva Leite, Bruno Penna, Ana Maria Reis Ferreira   +7 more
wiley   +1 more source