Results 101 to 110 of about 116,921 (275)
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, EarlyView.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
工程科学与技术ObjectiveCarbonaceous mudstone exhibits low mechanical strength, water-induced disintegration, and reduced structural compactness. It is widely distributed in the mountainous strata of Southwestern China, where tunneling activities frequently traverse ...
YU Mingyuan +4 more
doaj
CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
Advanced Science, EarlyView.ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Овощи России, 2009 Plant cultivation that should be characterized by proper yield abilities is often limited in different arable lands for the reason of abiotic and biotic stress factors.
A.N. Ignatov +3 more
doaj +1 more source
A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation
Advanced Science, EarlyView.A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu +7 more
wiley +1 more source
Advanced Science, EarlyView.Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao +12 more
wiley +1 more source
The biomechanics of negative-pressure wound therapy
, 2011 Includes references.Despite the success of negative-pressure wound therapy, its mechanism of action remains unclear. The common perception that it reduces tissue pressure and increases perfusion has recently been challenged following the observation that
Kairinos, Nicolas
core
Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Advanced Science, EarlyView.Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source
Integration of Micro/Nano Pressure Sensor for Diabetes Patients Applications
IEEE Open Journal of NanotechnologyDiabetes is a metabolic disorder that inhibits the body’s capacity to produce an adequate amount of blood glucose. Indications of diabetes include heightened appetite, frequent urination, and increased thirst. The objective of this research was to
Srinivasa Rao Karumuri +2 more
doaj +1 more source
Computational Modeling of In Vitro Swelling of Mitochondria: A Biophysical Approach
Molecules, 2018 Swelling of mitochondria plays an important role in the pathogenesis of human diseases by stimulating mitochondria-mediated cell death through apoptosis, necrosis, and autophagy.
Vladimir I. Makarov +2 more
doaj +1 more source