Results 211 to 220 of about 99,961 (306)

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

open access: yesGlia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips   +9 more
wiley   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

open access: yesJournal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon   +9 more
wiley   +1 more source

Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state

open access: yesActa Crystallographica Section D, Volume 82, Issue 2, Page 140-150, February 2026.
Structural characterization of S. mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state and identifies a schistosome‐specific epitope.Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino‐acid ...
Kelly L. Parker   +7 more
wiley   +1 more source

Synechococcus Under Stress: Contrasting Physiological and Transcriptional Responses to Salinity and Temperature in Marine Versus Euryhaline Strains

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Two model strains of Synechococcus sp.—the marine RS9907 and the euryhaline WH5701—exhibit distinct physiological responses to salinity after long acclimations at optimal and cold growth temperatures. Transcriptomic and photochemical analyses reveal drastic differences in their regulatory strategies and photosynthetic activity across a salinity ...
Isabel Escribano‐Gómez   +6 more
wiley   +1 more source

Osmotic Shock Induces G1 Arrest through p53 Phosphorylation at Ser33 by Activated p38MAPK without Phosphorylation at Ser15 and Ser20 [PDF]

open access: hybrid, 2001
Hiroto Kishi   +6 more
openalex   +1 more source

Unravelling echinoid mass mortalities: a global overview of mechanisms, spatio‐temporal trends, and taxonomic insights

open access: yesBiological Reviews, Volume 101, Issue 1, Page 221-236, February 2026.
ABSTRACT Mass mortality events (MMEs) have been occurring since the dawn of time. However, in contrast to terrestrial events, most marine MMEs remain undetected, largely due to the inaccessibility of many marine environments. One of the most notorious and best‐studied marine MMEs in modern times is that of the population collapse of the echinoid ...
Lisa‐Maria Schmidt   +2 more
wiley   +1 more source

Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth. [PDF]

open access: yesNat Commun
Demirbas B   +7 more
europepmc   +1 more source

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