Results 71 to 80 of about 99,961 (306)

Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 [PDF]

, 2017
We thank Zhen-Yuan Lin for help in the preparation of the AP-MS samples, and Cathy Collins for technical assistance. MDL is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), LEC is supported by a Canada Research Chair in ...
Bohovych, Iryna, Cowen, Leah E., Gingras, Anne-Claude, Khalimonchuk, Oleh, Lambert, Jean-Philippe, Leach, Michelle, Wong, Erin O Y, Xie, Jinglin L   +7 more
core   +4 more sources

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Microtiter miniature shaken bioreactor system as a scale-down model for process development of production of therapeutic alpha-interferon2b by recombinant Escherichia coli

BMC Microbiology, 2018
Background Demand for high-throughput bioprocessing has dramatically increased especially in the biopharmaceutical industry because the technologies are of vital importance to process optimization and media development. This can be efficiently boosted by
Joo Shun Tan, Sahar Abbasiliasi, Saeid Kadkhodaei, Yew Joon Tam, Teck-Kim Tang, Yee-Ying Lee, Arbakariya B. Ariff   +6 more
doaj   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Desiccation resistance and persistence of Cronobacter species in infant formula [PDF]

, 2009
Cronobacter is a newly described genus which includes opportunistic pathogens formerly known as ‘Enterobacter sakazakii’. These organisms have been isolated from a wide variety of sources, including powdered infant formula (PIF).
Forsythe, S, Osaili, T
core   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Oxidative stress and the presence of bacteria increase gene expression of the antimicrobial peptide aclasin, a fungal CSαβ defensin in Aspergillus clavatus [PDF]

PeerJ, 2019
Background Antimicrobial peptides (AMPs) represent a broad class of naturally occurring antimicrobial compounds. Plants, invertebrates and fungi produce various AMPs as, for example, defensins. Most of these defensins are characterised by the presence of
Gabriela Contreras, Nessa Wang, Holger Schäfer, Michael Wink   +3 more
doaj   +2 more sources

The Rate of Osmotic Shock Determines Bacterial Survival [PDF]

Biophysical Journal, 2014
Mechanosensitive (MS) channels allow cells to sense and respond to environmental changes. In bacteria, these channels are believed to protect against an osmotic shock. The physiological function of these channels has been primarily characterized by a standardized assay, where aliquots of batch cultured cells are rapidly pipetted into a hypotonic medium.
Lee, Heun Jin, Bialecka-Fornal, Maja, Phillips, Rob   +2 more
openaire   +2 more sources

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration

Nature Communications, 2022
Pollen grains undergo desiccation and rehydration prior to germination and must survive osmotic shock. Here the authors show that the Qc-SNARE protein SYP72 is required for the localization of the mechanosensitive channel MSL8 at the plasma membrane and ...
Xuemei Zhou, Yifan Zheng, Ling Wang, Haiming Li, Yingying Guo, Mengdi Li, Meng-xiang Sun, Peng Zhao   +7 more
doaj   +1 more source