Results 81 to 90 of about 99,961 (306)

Agarose Hydrogel Protects Protein Crystals From Osmotic Shock [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
High-throughput protein X-ray crystallography offers an unprecedented opportunity to facilitate drug discovery. The most reliable approach is to determine the three-dimensional (3D) structure of the protein-ligand complex by soaking the ligand in apo-crystals, but many lead compounds are not readily water-soluble.
Shigeru Sugiyama, Takuya Terai, Hiroyoshi Matsumura, Mihoko Maruyama, Yoshinori Takahashi, Hiroshi Yoshikawa, Masashi Yoshimura, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Tetsuo Nagano, Yusuke Mori   +12 more
openaire   +1 more source

Differential Gene Expression in Liver, Gill, and Olfactory Rosettes of Coho Salmon (Oncorhynchus kisutch) After Acclimation to Salinity. [PDF]

, 2015
Most Pacific salmonids undergo smoltification and transition from freshwater to saltwater, making various adjustments in metabolism, catabolism, osmotic, and ion regulation. The molecular mechanisms underlying this transition are largely unknown.
Bammler, Theo K, Beyer, Richard P, Farin, Federico M, Gallagher, Evan P, Hardiman, Gary, Lavado, Ramon, Maryoung, Lindley A, Schlenk, Daniel, Stapleton, Patricia L   +8 more
core   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

On the theory of solitons of fluid pressure and solute density in geologic porous media, with applications to shale, clay and sandstone

, 2016
In this paper we propose the application of a new model of transients of pore pressure p and solute density \r{ho} in geologic porous media. This model is rooted in the non-linear waves theory, the focus of which is advection and effect of large pressure
Caserta, A., Kanivetsky, R., Salusti, E.
core   +1 more source

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

NFAT5 genes are part of the osmotic regulatory system in Atlantic salmon (Salmo salar) [PDF]

, 2016
Acknowledgements This study was supported by a grant from the Biotechnology and Biological Sciences Research Council (BBSRC, BB/H008063/1), UK to DGH and SAM. Funding also came from Research Council Norway for project number 241016 for DGH and EJ.
Hazlerigg, David G, Jordan, William C, Jørgensen, Even H, Lorgen, Marlene, Martin, Samuel A M   +4 more
core   +2 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Mechanical stability of individual bacterial cells under different osmotic pressure conditions: a nanoindentation study of Pseudomonas aeruginosa

Beilstein Journal of Nanotechnology
Nanomechanical maps to test the mechanical response of the outer envelope of Pseudomonas aeruginosa were obtained utilizing atomic force microscopy in force–volume mode in the low range of loading forces when exposed to hypotonic (Milli-Q water ...
Lizeth García-Torres, Idania De Alba Montero, Eleazar Samuel Kolosovas-Machuca, Facundo Ruiz, Sumati Bhatia, Jose Luis Cuellar Camacho, Jaime Ruiz-García   +6 more
doaj   +1 more source

Osmotic shock stimulates de novo synthesis of two cardiolipins in an extreme halophilic archaeon

Journal of Lipid Research, 2004
The present report illustrates the response to osmotic stress of an extreme halophilic archaeon, Halorubrum sp., isolated from the saltern ponds of Margherita di Savoia in southern Italy.
Patrizia Lopalco, Simona Lobasso, Francesco Babudri, Angela Corcelli   +3 more
doaj   +1 more source

Stimulation of Thyroidal Phospholipid Turnover by Osmotic Shock

Journal of Biological Chemistry, 1970
Abstract In studying the control of thyroidal phosphatide metabolism it was found that osmotic shock could stimulate the 32P incorporation into lipids of surviving thyroid slices. The nature of this effect and its relation to thyrotropin stimulation of phosphatide turnover was examined by first incubating calf thyroid slices in hypotonic or isotonic ...
openaire   +2 more sources