Results 61 to 70 of about 19,894 (201)

Calcificaciones heterotópicas en cirugía protésica de cadera: Prótesis bicénctricas vs híbridas [PDF]

, 1999
Realizamos el seguimiento clínico y radiológico de 202 pacientes a los que se implantó una Prótesis Total de Cadera cementada (PTC). Analizamos la presencia de calcificaciones heterotópicas (CH) y su graduación, estudiando separadamente prótesis híbridas
Galdo Pérez, M., Montero Furelos, Luis Angel, Sánchez Mozo, A., Yubero Pascual, J.   +3 more
core  

Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets [PDF]

, 2017
Loss-of-function mutations in GLI3 and IHH cause craniosynostois and reduced osteogeneiss, respectively. In this study, we show that ihh ligand, the receptor Ptch1 and Gli transcription factors are differentialyy expressed in embryonic mouse calvaria ...
Hasan, Md. Rakibul, Kesper, Dorthe A., Kobayashi, Yukiho, Mustonen, Tuija, Rice, David P., Takatalo, Maarit, Veistinen, Lotta K., Vortkamp, Andrea   +7 more
core   +1 more source

Evaluation of clinical cardiac safety of zilurgisertib, an activin receptor‐like kinase‐2 (ALK2) inhibitor, in healthy participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract The oral, small molecule inhibitor of activin receptor‐like kinase‐2, zilurgisertib (INCB000928), is under evaluation in fibrodysplasia ossificans progressiva. Cardiac safety was assessed using electrocardiogram (ECG) parameters and a plasma concentration‐heart rate‐corrected QT (C‐QTc) interval analysis of pooled data from single ascending ...
Yan‐ou Yang, Hong Yang, Xing Liu, Xiaohua Gong, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Wound breakdown reconstructed by reverse lateral arm flap after excision of heterotopic ossification of the elbow following severe burn injury: A case report

Burns Open, 2017
We report the case of a wound complication that was reconstructed by reverse lateral arm flap after excision of heterotopic ossification (HO) of the elbow in a patient with severe burns.
Akihiro Hirakawa, Yoshiyuki Ohno, Shingo Komura, Haruhiko Akiyama   +3 more
doaj   +1 more source

Heterotopic Ossification Causing Radiculopathy after Lumbar Total Disc Arthroplasty [PDF]

Asian Spine Journal, 2015
To date, no reports have presented radiculopathy secondary to heterotopic ossification following lumbar total disc arthroplasty. The authors present a previously unpublished complication of lumbar total disk arthroplasty (TDA) secondary to heterotopic ...
Keith L. Jackson, Justin M. Hire, Jeremy M. Jacobs, Charles C. Key, John G. DeVine   +4 more
doaj   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, Volume 13, Issue 3, 14 January 2026.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis

Journal of Orthopaedic Surgery and Research, 2018
Background This meta-analysis aimed to assess whether the specific nonsteroidal anti-inflammatory drug (NSAID) naproxen has a role in reducing the occurrence of heterotopic ossification after hip surgery.
Ran Ma, Guan-Hong Chen, Liu-Jing Zhao, Xi-Cheng Zhai   +3 more
doaj   +1 more source

Heterotopics Osifications in revision surgery of total hip arthroplasty, with the aplication of Stimulan during the wound closure, performed in the Hospital Militar, since 2010 to 2014 [PDF]

, 2015
Las infecciones periprotésicas (IPP) constituyen una complicación devastadora en los procedimientos de reemplazo articular de cadera, con un aumento importante de las comorbilidades y de la mortalidad de nuestros pacientes, adicionalmente los ...
Valiente Ortega, Michel, Vallejo, Pablo
core  

Sudden death of a swimmer in water caused by heterotopic intracranial ossification and anomaly of the skull base [PDF]

, 2011
Background. Expression of immersion syndrome implies sudden and unexpected death of swimmer in water. A drowned swimmer is still a riddle for the forensic and clinical doctors.
Budakov Branislav, Gvozdenović Ljiljana, Mihalj Marija, Pilija Vladimir, Savović Slobodan   +4 more
core   +1 more source

First‐In‐Human Study to Assess the Pharmacokinetics and Safety of DS‐6016a After Single Subcutaneous Injection in Healthy Japanese Adults

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Fibrodysplasia ossificans progressiva is a rare, progressive autosomal dominant genetic disease caused by an activin receptor‐like kinase 2 (ALK2) mutation with a need for effective prophylactic therapies. This single‐center, randomized, double‐blind, placebo‐controlled study evaluated the pharmacokinetics and safety of DS‐6016a, a novel ...
Kei Okita, Hidetoshi Furuie, Akifumi Kurata, Yasuko Owada, Satoshi Yoshiba, Kei Furihata, Takaaki Oka, Yushi Kashihara, Hitoshi Ishizuka, Kazutaka Yoshihara   +9 more
wiley   +1 more source