Results 81 to 90 of about 20,314 (220)

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1339-1351, May 2026.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang, Yunlan Fang, Phillip Wang, Xiang Liu, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Efficacy Comparison of Open Reduction and Robot‐Aided Infra‐Acetabular and Posterior Column Screws Fixation in Complex Acetabular Fractures Surgery: Union Plate Versus Reconstruction Plate

Orthopaedic Surgery, Volume 18, Issue 5, Page 999-1009, May 2026.
Robot‐aided technology allowed for precise and minimally invasive placement of periarticular long screws in open surgery for complex acetabular fractures, while using the Union Plate could decrease operation difficulty (fewer channel adjustments, less time for robotic manipulation and intraoperative plate contouring), operation time, and bleeding.
Jianan Chen, Yiran Feng, Runlin Zhu, Pengqing Zhang, Zhihua Zhao, Ziming Zhang, Xiaodong Guo, Lulu Tang, Kaifang Chen   +8 more
wiley   +1 more source

Effectiveness of radiotherapy to prevent recurrence of heterotopic ossification in patients with spinal cord injury and traumatic head injury: A retrospective case-controlled study

Journal of Rehabilitation Medicine, 2020
Objective: To evaluate recurrence and early post-operative complications (sepsis) following surgical excision combined with radiotherapy for trouble-some hip heterotopic ossification in patients with spinal cord injury and traumatic brain injury. Design:
Thibaud Honore, Marjorie Salga, Amandine Grelier, Philippe Denormandie, Guillaume Genet, Alain Labib, Isabelle Bonan, Francois Genet   +7 more
doaj   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, Volume 13, Issue 21, 13 April 2026.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Myositis ossificans circumscripta of the buccinator muscle: first report of a rare complication of mandibular third molar extraction. [PDF]

, 2008
Myositis ossificans is a self-limiting ossifying process that most often develops following mechanical trauma to skeletal musculature. It chiefly affects the skeletal muscles of extremities of young athletically active adult males. Myositis ossificans is
Abramovitch, Kenneth, Bouquot, Jerry, Thurber, David, Vigneswaran, Nadarajah, Wiggins, Raymond L   +4 more
core   +1 more source

Combined medial collateral ligament and posterior oblique ligament reconstruction demonstrates favourable patient‐reported outcomes and medial knee stability in Grade III injuries: A systematic review

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 4, Page 1292-1309, April 2026.
Abstract Purpose To assess clinical and functional outcomes of combined medial collateral ligament and posterior oblique ligament (MCL–POL) reconstruction in isolated and multiligamentous Grade III medial knee injuries. Methods A systematic review was conducted according to PRISMA and Cochrane guidelines. MEDLINE, EMBASE and CENTRAL were searched to 13
Ayomide Michael Ade‐Conde, Michelle Cruickshank, Marc Daniel Bouchard, Prushoth Vivekanantha, Meshal Alomari, Darren de SA, Jeffrey Kay   +6 more
wiley   +1 more source

Bone Morphogenetic Protein (BMP) 9 Outperforms BMP2 in Osteogenesis and Osseointegration: In Vitro and In Vivo

Clinical Implant Dentistry and Related Research, Volume 28, Issue 2, April 2026.
ABSTRACT Objectives This study compared the osteogenic mechanisms and preclinical efficacy of bone morphogenetic protein 9 (BMP9) and BMP2 in vitro and in a beagle peri‐implant defect model in vivo. Materials and Methods In vitro, MC3T3‐E1 preosteoblasts were treated with BMP2 or BMP9 to assess osteogenic gene expression (Col1, Runx2, Alp, Ocn) by real‐
Hee‐seung Han, Dong Woo Lee, Yu‐Bin Kim, Sanghui Seok, Jeong Yeon Park, Sungtae Kim, Jue Yeon Lee, Yoon Jeong Park, Chong Pyung Chung, Young‐Dan Cho   +9 more
wiley   +1 more source

استخوان سازی هتروتوپيک مفصل ران به دنبال تشنج ناشی از مسموميت با اندوسولفان 1388 [PDF]

, 2011
مقدمه: استخوان‌سازی هتروتوپيک ( Heterotopic ossification ) به ايجاد استخوان در خارج سيستم اسکلتی اطلاق می‌شود. اندوسولفان ( Endosulfan ) يک سم آفت کش از خانواده ارگانوکلرين (organochlorine) است که در صورت ايجاد مسموميت، علايم سميت نورولوژيک آن غالب بوده ...
بزرگی, فرزاد, مبينی, مریم   +1 more
core  

MASSIVE POSTTRAUMATIC HETEROTOPIC OSSIFICATION OF KNEE JOINT (CASE REPORT)

Travmatologiâ i Ortopediâ Rossii, 2017
Heterotopic ossification is characterized by bone tissue formation in soft tissues that possess no osteogenic properties. The authors present a clinical case of a female patient with massive heterotopic ossification in anteromedial aspect of the right ...
M. S. Ryazantsev, N. Magnitskaya, A. P. Afanasyev, D. O. Ilʼin, A. N. Logvinov, A. V. Frolov, А. V. Korolev   +6 more
doaj   +1 more source

Atypical Presentation and Management of Fibrodysplasia Ossificans Progressiva [PDF]

, 2017
We report a case of an 18-year-old woman, with bilateral acute inflammatory pain on the hip area, during the premenstrual period, and progressive increase in volume and rigidity of both hips. Bilateral exuberant soft tissue calcifications were present on
Arcângelo, J, Grenho, A, Martins, A
core   +1 more source