Results 151 to 160 of about 145,230 (316)

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi   +10 more
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

open access: yesArthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat   +14 more
wiley   +1 more source

Efeito agudo da estimulação elétrica nervosa transcutânea (TENS) no desempenho funcional em idosos com osteoartrite de joelho: um estudo clínico randomizado [PDF]

open access: yes, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Objetivos: Investigar o efeito agudo da Estimulação Elétrica Nervosa Transcutânea (TENS) no desempenho funcional em idosos com Osteoartrite (OA) de joelho.
Ferronato, Letícia
core  

Behavioral Incentives for Exercise and Intra‐Articular Glucocorticoids for Knee Osteoarthritis: Results From a Factorially Designed Pragmatic Randomized Clinical Trial

open access: yesArthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to determine the benefit of a behaviorally designed incentive program and glucocorticoid injections in reducing symptoms and promoting physical activity in patients with knee osteoarthritis (KOA). Methods This was a pragmatic, multisite, factorially designed, blinded, randomized clinical trial.
Joshua F. Baker   +17 more
wiley   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

open access: yesArthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila   +12 more
wiley   +1 more source

Optimization of Arthroscopic All‐Inside Meniscus Repair With a Probe

open access: yesArthroscopy Techniques, EarlyView.
Abstract Meniscal preservation is essential for knee function and long‐term joint health. All‐inside meniscus repair achieves outcomes comparable to the inside‐out technique, but technical challenges remain, including limited working space, suture cut‐out in degenerative tissue, unfavorable suture angles, and risk of cartilage injury or arthroscope ...
Hui‐Shan Angela Lim   +1 more
wiley   +1 more source

Machine learning analysis of FOSL2 and RHoBTB1 as central immunological regulators in knee osteoarthritis synovium

open access: yesJournal of International Medical Research
Background Knee osteoarthritis is a debilitating disease with a complex pathogenesis. Synovitis, which refers to inflammation of the synovial membrane surrounding the joint, is believed to play an important role in the development and progression of knee
Kun Gao   +4 more
doaj   +1 more source

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