Results 131 to 140 of about 755,044 (345)

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank [PDF]

, 2019
Knee pain is one of the most common musculoskeletal complaints that brings people to medical attention. Approximately 50% of individuals over the age of 50 report an experience of knee pain within the past 12 months.
A Chen, AG Day-Williams, AM Valdes, AM Valdes, arcOGEN Consortium., B Heidari, B Mikic, C Bycroft, C Gonzaga-Jauregui, C Jinks, CA Thorstensson, CJ Saunders, D Prieto-Alhambra, E Evangelou, E Zengini, F Margheri, GA Hawker, GBD 2016 Disease and Injury Incidence and Prevalence Collaborators., H Iijima, H Miranda, I Meulenbelt, I Tachmazidou, IJ Wallace, J Bedson, J Loughlin, J Zheng, JA Zeni Jr., JM Jordan, JN Baldwin, K Magnusson, K Watanabe, KWD Ho, LR Thompson, LT Ho-Pham, M Nakajima, MS Yau, NM Warrington, P Gormley, P Suri, RJ Egli, RL Neame, S Ikegawa, SK Pregizer, SM Bindawas, T Neogi, TD Capellini, TD Spector, US Nguyen, W Meng, Y Miyamoto, Y Miyamoto   +50 more
core   +3 more sources

Laser‐Induced Periodic Phase‐Transition of 2D‐MoTe2 Nanograting Template for Frequency‐Shift Digital‐SERS Immunoassay of Autoimmune Disease

Advanced Science, EarlyView.
A protocol of fs‐laser‐induced periodic phase‐transition of 2D‐MoTe2 template, inducing AuNPs@1T’‐MoTe2 nanograting, is developed. The labeled AuNPs@1T’‐MoTe2 substrate conjugated with specialized immunoglobulin G demonstrates an unexpectedly high discrimination accuracy close to unity for serological diagnosis of rheumatoid arthritis by frequency ...
Yao Yao, Lulu Cao, Xiaolin Sun, Qiang Wang, Zhiyang Xu, Tianrui Zhai, Yan Zhao, Yijian Jiang, Zhanguo Li, Yinzhou Yan   +9 more
wiley   +1 more source

Weight, height, waist circumference: association with knee osteoarthritis findings from the osteoarthritis initiative

PAIN Reports
. Introduction:. Global prevalence of knee osteoarthritis is more than 300 million. Uncontrollable risk factors include age, sex, and height. Controllable risk factors include trauma, weight, and waist circumference. Objectives:.
Lisa H. Antoine, Kristen Allen Watts, Deanna D. Rumble, Taylor Buchanan, Andrew Sims, Burel R. Goodin   +5 more
doaj   +1 more source

Is home-based, high-intensity interval training cycling feasible and safe for patients with knee osteoarthritis? Study protocol for a randomized pilot study [PDF]

, 2017
Background: Osteoarthritis (OA) is a degenerative joint disease affecting the knee joint of many middle-aged and older adults. As OA symptoms typically involve knee pain and stiffness, individuals with knee OA are often insufficiently physically active ...
Grigg, Josephine, Keogh, Justin W.L., Vertullo, Christopher J.   +2 more
core   +1 more source

Fully automatic knee osteoarthritis severity grading using deep neural networks with a novel ordinal loss

Comput. Medical Imaging Graph., 2019
Knee osteoarthritis (OA) is one major cause of activity limitation and physical disability in older adults. Early detection and intervention can help slow down the OA degeneration.
Pingjun Chen, Linlin Gao, Xiaoshuang Shi, K. Allen, Lin Yang   +4 more
semanticscholar   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Notchplasty for the Arthroscopic Treatment of Limited Knee Extension

Arthroscopy Techniques, 2017
Knee osteoarthritis may lead to narrowing of the intercondylar notch due to osteophyte formation, thereby causing changes in native knee biomechanics.
Marcio B. Ferrari, M.D., Sandeep Mannava, M.D., Ph.D., Nicholas DePhillipo, M.S., A.T.C., George Sanchez, B.S., Robert F. LaPrade, M.D., Ph.D.   +4 more
doaj   +1 more source